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Effect of prenatal hypoxia on DNA synthesis in the tracheal epithelium and LPO-AOD system in the lungs of newborn rats

  • Experimental Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Newborn rats euthanized 24 h after birth were examined. The rats were born to females exposed to chronic hypobaric hypoxia on days 14–19 of gestation. The index of nuclei labeled with3H-thymidine in the tracheal epithelium of newborn rats exposed to prenatal hypoxia was 3 times lower than in the control. The LPO level was higher in posthypoxic animals than in intact rats. Prenatal hypoxia led to the suppression of antioxidant defense in the lungs of newborn rats.

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Authors and Affiliations

  1. Institute of Mother and Child Protection, Siberian Branch of the Russian Academy of Medical Sciences, Khabarovsk

    O. A. Lebed'ko & S. S. Timoshin

Authors
  1. O. A. Lebed'ko
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  2. S. S. Timoshin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 531–533, May, 1994

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Lebed'ko, O.A., Timoshin, S.S. Effect of prenatal hypoxia on DNA synthesis in the tracheal epithelium and LPO-AOD system in the lungs of newborn rats. Bull Exp Biol Med 117, 530–532 (1994). https://doi.org/10.1007/BF02444309

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  • DOI: https://doi.org/10.1007/BF02444309

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