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A chronobiological study of cell multiplication in esophageal epithelium of mice given lomefloxacin at different times of the day

  • Experimental Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The diurnal rhythmic pattern of cell division is preserved after both afternoon and night injection of lomefloxacin, but a rightward phasic shift of the diurnal rhythm is observed, the amplitude of rhythmic fluctuations being unchanged. In both cases the mesor of the mitotic index virtually does not, differ from that of the control, and the pool of dividing cells over 24 hours and throughout the follow-up period is even larger than the control values, which attests to a high adaptive potential of the proliferative system of esophageal epithelium.

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Authors and Affiliations

  1. Department of Biology, Medico-Biological Faculty, Russian State Medical University, Moscow

    Yu. A. Romanov, O. A. Irikov & S. S. Filippovich

Authors
  1. Yu. A. Romanov
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  2. O. A. Irikov
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  3. S. S. Filippovich
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 527–530, May, 1994

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Romanov, Y.A., Irikov, O.A. & Filippovich, S.S. A chronobiological study of cell multiplication in esophageal epithelium of mice given lomefloxacin at different times of the day. Bull Exp Biol Med 117, 526–529 (1994). https://doi.org/10.1007/BF02444308

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  • DOI: https://doi.org/10.1007/BF02444308

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