Abstract
The effect of carbachol, forskolin, and cycloheximide on IgE biosynthesis is studied in hay fever patients. The effect of carbachol is noted only for significant synthesis of IgEde novo. The administration of forskolin causes the inhibition of both IgE and IgG spontaneous production, while subsequent administration of carbachol neutralizes this effect. Whende novo IgE synthesis is absent, the degradation of IgE in the culture of peripheral blood mononuclear cells decreases significantly in the presence of cycloheximide.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 508–509, May, 1994
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Ado, A.D., Pol'ner, A.A. & Savel'eva, V.F. Effect of some cholinergic substances on spontaneous immunoglobulin E production by mononuclear cells of the peripheral blood in hay fever patients. Bull Exp Biol Med 117, 506–508 (1994). https://doi.org/10.1007/BF02444302
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DOI: https://doi.org/10.1007/BF02444302