Tolerance for opiate analgesia: Complex effect of antagonists of receptors for excitatory amino acids

  • A. Yu. Bespalov
  • E. E. Zvartau
  • M. A. Dumpis
  • L. B. Piotrovskii


The effect of excitatory amino acid receptor antagonists on the development of the conditioned reflex component of the tolerance for morphine analgesia is studied. It is demonstrated that the antagonists of NMDA and non NMDA receptors reduce the development of associated component of the tolerance, while the magnitude of the nonassociative component changes after co-administration of morphine with NMDA receptor antagonists.

Key Words

antagonists of EAA receptors opiates analgesia tolerance learning 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • A. Yu. Bespalov
    • 1
  • E. E. Zvartau
    • 1
  • M. A. Dumpis
    • 1
  • L. B. Piotrovskii
    • 1
  1. 1.I. P. Pavlov Medical Institute: Institute of Experimental MedicineRussian Academy of Medical SciencesSt. Petersburg

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