Skip to main content
Log in

Oxyferriscorbone: Ulcerostatic effect and its possible mechanisms

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is found that oxyferriscorbone inhibits free-radical lipid peroxidation in blood plasma and gastric tissue. Interaction of the drug with modeled membranes is demonstrated. It is suggested that this effect underlies the mechanism of its ulcerostatic action.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. A. A. Boldyrev, A. V. Lebedev and V. V. Ritov,Vopr. Med. Khim.,15, No 6, 622–626 (1969).

    PubMed  CAS  Google Scholar 

  2. I. M. Buzhurina and M. A. Panov, in:Physicochemical Methods of Molecular Biology [in Russian], Moscow (1978), pp. 41–56.

  3. Yu. A. Vladimirov and A. I. Archakov,Lipid Peroxidation in Biological Membranes [in Russian], Moscow (1972).

  4. Yu. A. Vladimirov and A. I. Dobretsov,Fluorescent Methods in the Study of Biological Membranes [in Russian], Moscow (1980).

  5. P. M. Kruglyakov and Yu. G. Rovin,Physicochemistry of the Black Hydrocarbon Pellicle (Biomolecular Lipid Membranes) [in Russian], Moscow (1978).

  6. E. A. Liberman and V. P. Topaly,Biofizika,14, No 3, 452–461 (1969).

    PubMed  CAS  Google Scholar 

  7. V. K. Lishko,The Sodium Pump of Biological Membranes [in Russian], Kiev (1977).

  8. A. M. Spivak, T. M. Galetskaya, N. A. Lyashko, and V. I. Okhon'ko,Vrach. Delo, No 4, 19–22 (1973).

    PubMed  CAS  Google Scholar 

  9. Ch. Shimane, V. I. Pasechnik, and S. El-Karagadi,Biofizika,29, No 3, 419–423 (1984).

    PubMed  CAS  Google Scholar 

  10. A. D. Bangham,Prog. Biophys. Mol. Biol.,18, 29–95 (1968).

    Article  CAS  Google Scholar 

  11. M. Hansen and A. L. Smith,Biochim. Biophys. Acta.,81, No 2, 214–221 (1964).

    CAS  Google Scholar 

  12. P. Mueller, D. O. Rudin, H. Ti. Tien, and W. C. Wescott,Nature,194, No 4832, 979–980 (1962).

    Article  PubMed  CAS  Google Scholar 

  13. M. Nishimura, T. Ito, and B. Chance,Biochim. Biophys. Acta.,59, No 1, 177–181 (1962).

    Article  PubMed  CAS  Google Scholar 

  14. K. Takagi, S. Okabe, and R. Saziki,Jap. J. Pharmacol.,19, 418–436 (1969).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 5, pp. 490–493, May, 1994

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rasulov, M.M., Kuznetsov, I.G., Zabozlaev, A.G. et al. Oxyferriscorbone: Ulcerostatic effect and its possible mechanisms. Bull Exp Biol Med 117, 487–490 (1994). https://doi.org/10.1007/BF02444296

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02444296

Key Words

Navigation