Abstract
Pretreatment of mice with aminooxyacetic acid enhances the antidote activity of diazepam against picrotoxin but not bicuculline. It is claimed that GABA-transaminase inhibitors may be promising candidates as an antidote in complex therapy of seizures induced by GABA-lytics blocking the chloride ionophore.
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References
A. I. Golovko, G. A. Sofronov, T. V. Nikolaeva, and T. V. Klyuntina,Byull. Eksp. Biol. Med.,113, No 2, 290 (1992).
G. N. Kryzhanovskii, M. N. Karpova, I. Yu. Abrosimov,et al., Byull. Eskp. Biol. Med.,115, No 3, 238 (1993).
R. Bernasconi, M. Klein, P. Martin,et al., J. Neural Transmiss.,72, No 3, 213 (1988).
V. P. Georgiev and N. D. LambadjievaNeuropharmacology,20, No 9, 813 (1981).
L. g. Miller, D. J. Greenblatt, J. G. Barnhill,et al., Europ. J. Pharmacol.,148, No 1, 123 (1988).
S. R. Pagliusi, C. Gomes, J. R. Leite, and G. Trolin,Naunyn-Schmiedelberg's Arch. Pharmak.,322, No 3, 210 (1983).
V. Paul and M. S. Krishnamoorthy,Indian J. Physiol. Pharmacol.,33, No 4, 243 (1989).
S. L. Peterson,Brain Res.,26, No 1, 43 (1991).
S. K. Rastogi and M. K. Ticku,Neuropharmacology,25, No 2, 175 (1986).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 4, pp. 441–443, April, 1994
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Golovko, A.I., Sofronov, G.A., Klyuntina, T.V. et al. Effect of aminooxyacetic acid on the antidote activity of diazepam under the action of GABA-lytics. Bull Exp Biol Med 117, 440–442 (1994). https://doi.org/10.1007/BF02444206
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DOI: https://doi.org/10.1007/BF02444206