Abstract
The cardioprotector effect of cytochromec during a 15-min complete blocking of the anterior descending branch of the left coronary artery was studied in rat experiments. Cytochromec in a dose of 20 mg/kg was found to noticeably reduce the necrosis zone 4 h after transitory ischemia. The protective effect of a single injection of cytochromec was virtually undetectable after 72, h, this pointing to the need for a course of treatment.
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References
V. V. Beregovykh, E. R. Davidov, S. P. Kudrin,et al., Khim.-Farm. Zh., No, 10, 14–22 (1990).
R. M. Imatdieva, in:Annual Conference of Young Scientists of the Research Center of Bioactive Substances. Proceedings [in Russian], Kupavna (1993), p. 24.
L. N. Sernov and V. V. Gatsura,Byull. Eksp. Biol. Med.,107, No 5, 534–535 (1989).
V. V. Beregovykh, E. R. Davidov, and L. N. SernovJ. Molec. Cell. Cardiol. 23, Suppl. IV, 89 (1991).
W. Bernauer,Arch. Pharmacol.,328, 288–294 (1985).
D. J. Hears, in:Myocardial Protection and Calcium Antagonists. International Symposium, Paris (1987), pp. 38–59.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No, 4, pp. 439–440, April, 1994
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Gatsura, V.V., Imatdieva, R.M. Effect of cytochromec on the necrosis zone in transitory myocardial ischemia. Bull Exp Biol Med 117, 438–440 (1994). https://doi.org/10.1007/BF02444205
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DOI: https://doi.org/10.1007/BF02444205