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Time course of the binding of some prostanoids in the serum of mice with lewis lung carcinoma with spontaneous metastases. Effect of exogenous prostaglandins on tumor dissemination

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that the ability of serum to bind some prostanoids changes depending on the stage of development of the primary tumor node. Surgical removal of the tumor modulates the binding of TxB2. When the PGE2 content increases in the organism, the PGE2 binding in the serum is stepped up, and dissemination is enhanced.

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Authors and Affiliations

  1. All-Russia Center for the Safety of Biologically Active Compounds, Moscow Region

    L. L. Mikhailevskaya, V. G. Vavilova, L. A. Selezneva & A. S. Kinzirskii

  2. Industrial Center for Medical Biotechnology, Moscow

    L. L. Mikhailevskaya, V. G. Vavilova, L. A. Selezneva & A. S. Kinzirskii

Authors
  1. L. L. Mikhailevskaya
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  2. V. G. Vavilova
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  3. L. A. Selezneva
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  4. A. S. Kinzirskii
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, № 3, pp. 296–298, March, 1994.

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Mikhailevskaya, L.L., Vavilova, V.G., Selezneva, L.A. et al. Time course of the binding of some prostanoids in the serum of mice with lewis lung carcinoma with spontaneous metastases. Effect of exogenous prostaglandins on tumor dissemination. Bull Exp Biol Med 117, 299–301 (1994). https://doi.org/10.1007/BF02444170

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  • DOI: https://doi.org/10.1007/BF02444170

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