Bulletin of Experimental Biology and Medicine

, Volume 117, Issue 3, pp 280–282 | Cite as

Regulation of the adenylate cyclase system in the lungs of rats treated with plague toxin

  • T. D. Cherkasova
  • V. A. Yurkiv
  • V. I. Pokrovskii
Microbiology and Immunology

Abstract

It is demonstrated that the “murine” lethal toxin ofYersinia pestis desensitizes the β-adrenergic receptors coupled to the pulmonary adenylate cyclase system. The degree of adenylate cyclase activation in rat pulmonary membrane preparation by isoproterenol or histamine and the number of β-adrenergic receptors decrease after a 2-h incubation with the toxin.

Key Words

plague toxin adenylate cyclase rat lungs β-adrenergic receptors histamine H1 receptors 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • T. D. Cherkasova
    • 1
  • V. A. Yurkiv
    • 1
  • V. I. Pokrovskii
    • 1
  1. 1.Central Institute of EpidemiologyMoscow

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