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Effect of long-term lovastatin treatment on the number of glucocorticoid receptors in peripheral blood lymphocytes

  • Pharmacology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A reduced number of3H-dexamethasone-specific binding sites (glucocorticoid receptors) in lymphocytes was observed after 2 months of lovastatin treatment against the background of a lowered serum level of cholesterol and triglycerides and a reduced rate of cholesterol synthesis in lymphocytes. This phenomenon is considered as an adaptive reaction of the cells to relative cholesterol depletion due to inhibition of its intracellular synthesis.

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Authors and Affiliations

  1. All-Russian Research Center of Preventive Medicine, Moscow

    E. V. Pozdeeva, I. E. Petrichenko, N. M. Akhmedzhanov, N. I. Zhidko & Yu. A. Shakhov

Authors
  1. E. V. Pozdeeva
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  2. I. E. Petrichenko
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  3. N. M. Akhmedzhanov
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  4. N. I. Zhidko
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  5. Yu. A. Shakhov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 3, pp. 271–274, March, 1994

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Pozdeeva, E.V., Petrichenko, I.E., Akhmedzhanov, N.M. et al. Effect of long-term lovastatin treatment on the number of glucocorticoid receptors in peripheral blood lymphocytes. Bull Exp Biol Med 117, 273–276 (1994). https://doi.org/10.1007/BF02444161

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  • DOI: https://doi.org/10.1007/BF02444161

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