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Increased generation of nitric oxide in tissues of rats following their adaptation to short-term stress (An EPR study)

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Adaptation of rats to short-term immobilization stress increases the ability of their isolated organs to generate nitric oxide (NO): its spontaneous release by the liver, gut, heart, and kidney tissues rises 2- to 4-fold and its carbachol-stimulated release by these tissues rises 4- to 5-fold. It is suggested that such adaptation leads to rapid NO generation in the adapted animal in response to exogenous or endogenous stimuli and thus increases the efficacy of defense reactions.

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Authors and Affiliations

  1. Laboratory of Cardiac Pathophysiology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    F. Z. Meerson, A. V. Lapshin, P. I. Mordvintsev, V. D. Mikoyan, E. B. Manukhina, L. N. Kubrina & A. F. Vanin

  2. Laboratory for Physical Chemistry of Biopolymers, Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    F. Z. Meerson, A. V. Lapshin, P. I. Mordvintsev, V. D. Mikoyan, E. B. Manukhina, L. N. Kubrina & A. F. Vanin

Authors
  1. F. Z. Meerson
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  2. A. V. Lapshin
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  3. P. I. Mordvintsev
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  4. V. D. Mikoyan
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  5. E. B. Manukhina
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  6. L. N. Kubrina
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  7. A. F. Vanin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, No 3, pp. 242–244, March, 1994

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Meerson, F.Z., Lapshin, A.V., Mordvintsev, P.I. et al. Increased generation of nitric oxide in tissues of rats following their adaptation to short-term stress (An EPR study). Bull Exp Biol Med 117, 243–245 (1994). https://doi.org/10.1007/BF02444151

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  • DOI: https://doi.org/10.1007/BF02444151

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