Bulletin of Experimental Biology and Medicine

, Volume 117, Issue 2, pp 118–121 | Cite as

Protective effect of adaptation to hypoxia and its prolongation by pharmacological agents in rats prone to audiogenic epilepsy

  • F. Z. Meerson
  • L. M. Mamalyga
Pathological Physiology and General Pathology


Cytophotometric determination of RNA in various brain structures of hypoxia-adapted and unadapted epilepsy-prone rats at different times after an epileptic seizure shows much smaller decreases in RNA levels and their much more rapid return to normal in the adapted than in the unadapted rats. The adaptation to hypoxia produces a marked anticonvulsive effect, and this effect is enhanced and prolonged considerably by pharmacotherapy.

Key Words

adaptation to hypoxia audiogenic epilepsy therapy 


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  1. 1.
    E. A. Gromova, V. A. Shabaeva, T. P. Semenova,et al., Dokl. Akad. Nauk. SSSR,262, No 1, 245–247 (1982).PubMedGoogle Scholar
  2. 2.
    V. A. Karlov,Epilepsy [in Russian], Moscow (1990).Google Scholar
  3. 3.
    G. N. Kryzhanovskii,Determinant Structures in Nervous System Pathology: Generator Mechanisms of Neuropathological Syndromes [in Russian], Moscow (1980).Google Scholar
  4. 4.
    L. M. Mamalyga,Kosm. Biol., No 3, 61–64 (1988).Google Scholar
  5. 5.
    M. D. Mashkovskii,Medicaments [in Russian], Moscow (1991).Google Scholar
  6. 6.
    F. Z. Meerson,The General Mechanism of Adaptation and Prophylaxis [in Russian], Moscow (1973).Google Scholar
  7. 7.
    F. Z. Meerson,The Concept of Long-Term Adaptation [in Russian], Moscow (1993).Google Scholar
  8. 8.
    F. Z. Meerson, V. G. Pinelis, V. B. Koshelev,et al., Byull. Eksp. Biol. Med.,116, No 12, 572–574 (1993).Google Scholar
  9. 9.
    F. Z. Meerson, V. P. Pozharov, T. D. Minyailenko, L. Yu. Golubeva,, pp. 574–577.Google Scholar
  10. 10.
    F. Z. Meerson, E. V. Shabunina, L. M. Belkina and M. G. Pshennikova,Kardiologiya, No 5, 87–89 (1987).Google Scholar
  11. 11.
    G. Berub, M. Powers, J. Kerkay and G. Clark,Stain Technol.,41, No 6, 73–81 (1966).Google Scholar
  12. 12.
    F. Z. Meerson, in:Adaptation, Stress and Prophylaxis, Springer Verlag, Berlin (1984).Google Scholar
  13. 13.
    F. Z. Meerson,Adaptive Protection of the Heart: Protecting Stress and Ischemic Damage, CRC Press, Boca Raton (1991).Google Scholar
  14. 14.
    F. Z. Meerson, E. E. Ustinova and E. N. Orlova,J. Clin. Cardiol.,10, No 2, 783–789 (1987).CrossRefGoogle Scholar
  15. 15.
    N. M. Sherwood and P. S. Timiras,A Stereotaxic Atlas of the Developing Rat Brain, London (1970).Google Scholar
  16. 16.
    N. Suthanthirorajan and S. Subranmanyam,J. Physiol. Pharmacol.,27, No 2, 101–108 (1983).Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • F. Z. Meerson
    • 1
  • L. M. Mamalyga
    • 1
  1. 1.Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow

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