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Bulletin of Experimental Biology and Medicine

, Volume 117, Issue 1, pp 45–47 | Cite as

Modulation of the oxidative burst in mouse macrophages and human neutrophils by superlow concentrations of GM1 ganglioside

  • N. F. Avrova
  • V. P. Ivanova
  • V. A. Tyurin
  • I. A. Gamalei
  • I. V. Klyubin
  • I. A. Shchepetkin
  • E. V. Borunov
  • Yu. Yu. Tyurina
Biophysics and Biochemistry

Abstract

It is shown that ganglioside GM1 in picomolar concentrations stimulates the phorbol-12-myristate-13-acetate (PMA)-induced generation of active forms of oxygen by neutrophils and peritoneal macrophages. GM1 (10−11 M) is found to enhance the luminol-dependent chemiluminescence induced by 10−8 M PMA in mouse macrophages in comparison with the effect of PMA alone.

Key words

gangliosides phagocytes oxidative burst 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • N. F. Avrova
    • 1
    • 2
    • 3
  • V. P. Ivanova
    • 1
    • 2
    • 3
  • V. A. Tyurin
    • 1
    • 2
    • 3
  • I. A. Gamalei
    • 1
    • 2
    • 3
  • I. V. Klyubin
    • 1
    • 2
    • 3
  • I. A. Shchepetkin
    • 1
    • 2
    • 3
  • E. V. Borunov
    • 1
    • 2
    • 3
  • Yu. Yu. Tyurina
    • 1
    • 2
    • 3
  1. 1.Laboratory of Comparative Biochemistry of the Nervous System, Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgUSSR
  2. 2.Laboratory of Cell PhysiologyInstitute of CytologySt. PetersburgUSSR
  3. 3.Laboratory of Immunology, Institute of Oncology, Tomsk Research CenterRussian Academy of Medical SciencesUSSR

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