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Neurological complications of liver transplantation

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Abstract

We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent complications were mental status changes ranging from delirium to coma and seizures. The aetiology was multifactorial, cyclosporin A neurotoxicity being the main cause. Patients with neurological complications had a higher mortality rate than those without. In our series, neurological complications represented a major medical problem with increased morbidity and mortality.

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Authors and Affiliations

  1. Servizio di Neurologia, Policlinico S. Orsola-Malpighi, Via Albertoni 15, I-40138, Bologna, Italy

    Maria Guarino, Andrea Stracciari, Paolo Pazzaglia & Roberto D’Alessandro

  2. Divisione di Neurologia, Ospedale Niguarda, Piazza Ospedale Maggiore 3, I-20162, Milan, Italy

    Roberto Sterzi, Ignazio Santilli & Franca Donato

Authors
  1. Maria Guarino
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  2. Andrea Stracciari
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  3. Paolo Pazzaglia
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  4. Roberto Sterzi
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  5. Ignazio Santilli
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  6. Franca Donato
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  7. Roberto D’Alessandro
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Guarino, M., Stracciari, A., Pazzaglia, P. et al. Neurological complications of liver transplantation. J Neurol 243, 137–142 (1996). https://doi.org/10.1007/BF02444004

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  • DOI: https://doi.org/10.1007/BF02444004

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