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Genetic mapping of thet-complex region on mouse chromosome 17 including theHybrid sterility-1 gene

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Abstract

t-haplotypes occupy a region on chromosome (Chr) 17 which slightly overlaps the ends of theT-H-2 interval. The wild-type form of this 14 centi-Morgan (cM) region was mapped in a multilocus backcross (C57BL/10-T×C3H)F1×C57BL/10 using 15 DNA probes on Southern blots of the DNA extracted from 53 animals which were recombinants in theT-H-2 interval. Each recombinant was also progenytested to ascertain itsHybrid sterility-1 (Hst-1) genotype by crossing to PWB/Ph, aMus musculus-derived inbred strain. The limit of resolution of the cross was 0.27 cM. The map distances have been determined for the DNA loci in theT-H-2 interval and theHst-1 gene was mapped in close vicinity to theD17Rp17 locus.

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Authors and Affiliations

  1. Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Vídenská 1083, 142 20, Prague 4, Czechoslovakia

    Jiři Forejt & Milada Loudová-Micková

  2. Abteilung Immungenetik, Max-Planck-Institut für Biologie, Corrensstrasse 42, D-7400, Tübingen, Germany

    Vladimir Vincek & Jan Klein

  3. Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, WC2A 3PX, London, UK

    Hans Lehrach

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  1. Jiři Forejt
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  2. Vladimir Vincek
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  3. Jan Klein
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  4. Hans Lehrach
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  5. Milada Loudová-Micková
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Forejt, J., Vincek, V., Klein, J. et al. Genetic mapping of thet-complex region on mouse chromosome 17 including theHybrid sterility-1 gene. Mammalian Genome 1, 84–91 (1991). https://doi.org/10.1007/BF02443783

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  • DOI: https://doi.org/10.1007/BF02443783

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