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Mammalian Genome

, 1:84 | Cite as

Genetic mapping of thet-complex region on mouse chromosome 17 including theHybrid sterility-1 gene

  • Jiři Forejt
  • Vladimir Vincek
  • Jan Klein
  • Hans Lehrach
  • Milada Loudová-Micková
Original Contributions

Abstract

t-haplotypes occupy a region on chromosome (Chr) 17 which slightly overlaps the ends of theT-H-2 interval. The wild-type form of this 14 centi-Morgan (cM) region was mapped in a multilocus backcross (C57BL/10-T×C3H)F1×C57BL/10 using 15 DNA probes on Southern blots of the DNA extracted from 53 animals which were recombinants in theT-H-2 interval. Each recombinant was also progenytested to ascertain itsHybrid sterility-1 (Hst-1) genotype by crossing to PWB/Ph, aMus musculus-derived inbred strain. The limit of resolution of the cross was 0.27 cM. The map distances have been determined for the DNA loci in theT-H-2 interval and theHst-1 gene was mapped in close vicinity to theD17Rp17 locus.

Keywords

Inbred Strain Recombinant Inbred Hybrid Sterility Recombinant Inbred Strain Wild Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc 1991

Authors and Affiliations

  • Jiři Forejt
    • 1
  • Vladimir Vincek
    • 2
  • Jan Klein
    • 2
  • Hans Lehrach
    • 3
  • Milada Loudová-Micková
    • 1
  1. 1.Institute of Molecular GeneticsCzechoslovak Academy of SciencesPrague 4Czechoslovakia
  2. 2.Abteilung ImmungenetikMax-Planck-Institut für BiologieTübingenGermany
  3. 3.Imperial Cancer Research Fund LaboratoriesLondonUK

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