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Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 6, pp 605–607 | Cite as

Physicochemical properties of membranes and functional status of liver mitochondria in rats with an inherited capacity for increased radical formation

  • R. I. Salganik
  • I. G. Shabalina
  • N. G. Kolosova
  • V. N. Solov'ev
  • N. A. Solov'eva
  • A. R. Kolpakov
Biophysics and Biochemistry
  • 19 Downloads

Abstract

Liver mitochondria of inbred W/SSM rats with inherited increased radical formation reveal the following anomalies: inhibition of oxidative phosphorylation, a lowered transmembrane potential, and alterations in protein-lipid interaction. The membrane viscosity and osmotic stability of mitochondria are unaffected.

Key Words

rats of the W/SSM strain oxygen radicals mitochondria oxidative phosphorylation membrane structure 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • R. I. Salganik
    • 1
    • 2
  • I. G. Shabalina
    • 1
    • 2
  • N. G. Kolosova
    • 1
    • 2
  • V. N. Solov'ev
    • 1
    • 2
  • N. A. Solov'eva
    • 1
    • 2
  • A. R. Kolpakov
    • 1
    • 2
  1. 1.Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirsk
  2. 2.Institute of Biochemistry; Institute of Regional Pathology and PathomorphologySiberian Division of the Russian Academy of Medical SciencesNovosibirsk

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