Letters in Peptide Science

, Volume 5, Issue 4, pp 259–262 | Cite as

Derivatives of aminoquinones with N-protected amino acids

  • Chrysostomos Pachatouridis
  • Elias A. Couladouros
  • Vassilios P. Papageorgiou
  • Maria Liakopoulou-Kyriakides
Article

Summary

The synthesis of derivatives of aminoquinones with N-protected amino acids is reported here. 2-Amino-1,4-benzoquinone and 2-amino-1,4-naphthoquinone, prepared by the azide method in yields of 60 and 95% respectively, were coupled with N-Boc-protected amino acids including glycine, serine, proline and tyrosine, to give the correspondening derivatives.N, N′-Diisopropylcarbodiimide/1-hydroxybenzotriazole orN, N′-dicyclohexylcarbodiimide/HOBt used as coupling reagents provided the expected products in satisfactory yields and purities as supported by TLC, HPLC and spectral analysis.

Key words

aminoquinones N-Protected amino acids quinonyl-amino acids 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Chrysostomos Pachatouridis
    • 1
  • Elias A. Couladouros
    • 2
  • Vassilios P. Papageorgiou
    • 1
  • Maria Liakopoulou-Kyriakides
    • 1
  1. 1.Department of Chemical EngineeringAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Chemistry LaboratoriesAgricultural University of AthensAthensGreece

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