Letters in Peptide Science

, Volume 4, Issue 2, pp 95–100 | Cite as

Engineering of zinc finger and MHC motifs to locked-in tertiary folds

  • Marc Mathieu
  • Christian Lehmann
  • Alain Razaname
  • Gabriele Tuchscherer


The assembly of helical and β-sheet peptide blocks containing reactive chain ends results in highly branched chain architectures (‘locked-in folds’) mimicking native tertiary structures. This molecular kit strategy allows to bypass the protein folding problem in protein de novo design and gives access to protein mimetics of high thermodynamic stability. The validity of this concept is exemplified for the design and synthesis of locked-in folds mimicking the zinc finger and MHC folding motifs.


Protein design Locked-in folds Chemoselective ligation Zinc finger motif MHC motif Protein mimetics Non-native architectures 


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Copyright information

© ESCOM Science Publishers B.V 1997

Authors and Affiliations

  • Marc Mathieu
    • 1
  • Christian Lehmann
    • 1
  • Alain Razaname
    • 1
  • Gabriele Tuchscherer
    • 1
  1. 1.Institute of Organic ChemistryUniversity of Lausanne, BCH-DorignyLausanneSwitzerland

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