Influence of proline and β-turn mimetics on the cyclization of penta- and hexapeptides
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Proline and Pro-derived peptidomimetics, such as meoxPro-Oic (4-methoxy-proline-octahydro indolic acid), and DBF (2-aminoethyl-6-dibenzofuran propionic acid) were introduced into thymopentin-derived penta-[SP5-] and hexa-[SP6-] peptides and penta-, hexa- and hepta-alanine. Surprisingly, we found that cyclomonomer formation in the investigated penta- and hexapeptides was drastically hindered by the presence of proline regardless of position.
Key wordsall-l-peptides DBF meoxPro-Oic turn-induction
electrospray ionization mass spectrometry
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