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Letters in Peptide Science

, Volume 4, Issue 4–6, pp 387–389 | Cite as

Preferential β-sheet structuration of multiconformational poly(Glu-Leu) by metallic ions

  • Marylène Bertrand
  • André Brack
Article
  • 20 Downloads

Summary

Alternating poly(Glu-Leu) exhibits a random coil structure in pure water at neutral pH. The addition of 0.5 equiv of Ca2+ induces a coil-to-β-sheet transition and the addition of 0.15 equiv of Fe3+ induces a coil-to-α-helix transition. Conformational competition between these two structures was studied by mixing preformed β-sheets and α-helices in different proportions. Circular dichroism spectra clearly show that β-sheets are favored at the expense of α-helices in β-sheet-rich mixtures.

Keywords

Anionic polypeptide Metallic ions Multiconformation Preference for β-sheets 

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References

  1. 1.
    Bertrand, M., Sy, D. and Brack, A., J. Pept. Res., 49 (1997) 269.PubMedCrossRefGoogle Scholar
  2. 2.
    Brack, A. and Trudelle, Y., Polym. Commun., 26 (1985) 369.Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Marylène Bertrand
    • 1
  • André Brack
    • 1
  1. 1.Centre de Biophysique MoléculaireOrléans Cedex 2France

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