Preferential β-sheet structuration of multiconformational poly(Glu-Leu) by metallic ions
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Alternating poly(Glu-Leu) exhibits a random coil structure in pure water at neutral pH. The addition of 0.5 equiv of Ca2+ induces a coil-to-β-sheet transition and the addition of 0.15 equiv of Fe3+ induces a coil-to-α-helix transition. Conformational competition between these two structures was studied by mixing preformed β-sheets and α-helices in different proportions. Circular dichroism spectra clearly show that β-sheets are favored at the expense of α-helices in β-sheet-rich mixtures.
KeywordsAnionic polypeptide Metallic ions Multiconformation Preference for β-sheets
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