Letters in Peptide Science

, Volume 4, Issue 4–6, pp 387–389 | Cite as

Preferential β-sheet structuration of multiconformational poly(Glu-Leu) by metallic ions

  • Marylène Bertrand
  • André Brack


Alternating poly(Glu-Leu) exhibits a random coil structure in pure water at neutral pH. The addition of 0.5 equiv of Ca2+ induces a coil-to-β-sheet transition and the addition of 0.15 equiv of Fe3+ induces a coil-to-α-helix transition. Conformational competition between these two structures was studied by mixing preformed β-sheets and α-helices in different proportions. Circular dichroism spectra clearly show that β-sheets are favored at the expense of α-helices in β-sheet-rich mixtures.


Anionic polypeptide Metallic ions Multiconformation Preference for β-sheets 


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  1. 1.
    Bertrand, M., Sy, D. and Brack, A., J. Pept. Res., 49 (1997) 269.PubMedCrossRefGoogle Scholar
  2. 2.
    Brack, A. and Trudelle, Y., Polym. Commun., 26 (1985) 369.Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Marylène Bertrand
    • 1
  • André Brack
    • 1
  1. 1.Centre de Biophysique MoléculaireOrléans Cedex 2France

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