Abstract
A system for the online, simultaneous and intermittent analysis of blood pH, pCO2 pO2 using two-way cyclic pumping of lactate Ringer as a baseline solution is described. The multi-gas sensor is composed of a pH-ISFET with a temperature sensor, a pH-ISFET-based pCO2 sensor and a Clark-type pO2 sensor, bundled in an epoxy rod, and held in place in a flow cell which is directly connectable to an indwelling cannula. The system is controlled by a microcomputer, which supervises pump operation, temperature-compensation of sensor outputs, one-point calibration using sampled blood analysis, and provides graphical display of monitored results. Results of arterial blood-gas monitoring for mongrel dogs are presented which demonstrate the reliability of the present system over extended periods.
Similar content being viewed by others
References
Ashwood, E., Kost, G. andKenny, M. (1983) Temperature correction of blood-gas and pH measurements.Clin. Chem.,29, 1877–1885.
Clark, J., Veasy, L., Jung, A. andJenkins, H. (1985) Online PO2, PCO2, and pH monitoring of infant.Comput. Biomed. Res.,4, 262–274.
Kohama, A., Nakamura, Y., Nakamura, M., Yano, M. andShibatani, K. (1984) Continuous monitoring of arterial and tissue PCO2.Crit. Care Med.,12, 940–942.
McKinley, B., Wong, K., Janata, J., Jordan, W. andWestenskow, D. (1981a)In vivo continuous monitoring of ionized calcium in dogs using ion sensitive field effect transistors.,9, 333–339.
McKinley, B., Houtchens, B. andJanata, J. (1981b) Continouous monitoring of interstitial fluid potassium during hemorrhagic shock in dogs.,9, 845–851.
Mindt, W. (1973) Sauerstoff-Sensor fürin vivo Messung. Proc. Jahrestagung Ges Biomed. Tech., Erlangen, 29–30.
Shimada, K., Matsuo, M. andEsashi, M. (1978) US Patent 4 218 298.
Shimada, K., Yano, M., Shibatani, K., Komoto, Y., Esashi, M. andMatsuo, T. (1980) Application of catheter-tip i.s.f.e.t. for continuousin vivo measurement.Med. & Biol. Eng. & Comput.,18, 741–745.
Sibbald, A., Covington, A. K. andCarter, R. F. (1985) Online patient-monitoring system for the simultaneous analysis of blood K+, Ca2+, Na+ and pH using a quadrupole-function ChemFET integrated-circuit sensor.,23, 329–338.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakamura, M., Yano, M., Shibatani, K. et al. Online pH,pCO2 andpO2 monitoring system using two-way cyclic pumping of lactate Ringer as a baseline solution. Med. Biol. Eng. Comput. 25, 45–50 (1987). https://doi.org/10.1007/BF02442819
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02442819