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Sampling: a critical problem in biosensing

Medical and Biological Engineering and Computing volume 28, pages B3–B9 (1990)Cite this article

Abstract

Biosensing is widely recognised to be of potentially major importance to medicine and related fields, but in spite of a large number of impressive and important advances, widespread practical application has lagged. We examine the thesis that ‘sampling’ is a process which involves all of the phenomena which are associated with the transport of analyte molecules to the active sensor site, and that problems associated with this process are now the limiting factor in further use of many existing biosensors. We conclude that an integrated process of sampling and sensing should be emphasised in developing new biosensing systems, and propose several new approaches.

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  1. Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

    J. C. Weaver

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  1. J. C. Weaver
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Weaver, J.C. Sampling: a critical problem in biosensing. Med. Biol. Eng. Comput. 28, B3–B9 (1990). https://doi.org/10.1007/BF02442674

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  • DOI: https://doi.org/10.1007/BF02442674

Keywords

  • Analyte transport
  • Biosensor
  • Cell growth
  • Cell secretion
  • Diffusion
  • Gel microdroplet
  • Invasive sensor
  • Sampling
  • Sampling process
  • Thermal diffusion probe