Medical and Biological Engineering and Computing

, Volume 20, Issue 6, pp 699–703 | Cite as

Design of a millivoltmeter which can record the electrogenic absorption of glucose from the intestine of human infants

  • G. C. Aucott
  • D. A. Ducker
  • A. S. McNeish


A millivoltmeter incorporating a dedicated microprocessor system has been developed which permits glucose-induced potential difference across the intestinal mucosa to be measured satisfactorily in newborn infants. This has allowed important data to be obtained about the function and development of the immature intestine.


Glucose absorption Intestine Potential difference 


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  1. Debnam, E. S. andLevin, R. J. (1975) An experimental method of identifying and quantifying the active transfer electrogenic component from the diffusive component during sugar absorption measuredin vivo.J. Physiol. 246, 181–196.Google Scholar
  2. Ducker, D. A., Hughes, C. A., Warren, I. andMcNeish, A. S. (1980) Neonatal gut function, measured by the one hour D(+)xylose test: influence of gestational age and size.Gut,21, 133–136.Google Scholar
  3. Igarashi, Y., Himukai, M. andKonno, T. (1981)In vivo recording of the glucose- and disaccharide-evoked potentials from the human jejunum in infancy.Eur. J. Pediatr.,135, 255–260.CrossRefGoogle Scholar
  4. Lifshitz, F. (1977) Carbohydrate problems in paediatric gastroenterology.Clin. Gastroenterol.,6, 415–429.Google Scholar
  5. McNeish, A. S., Ducker, D. A., Warren, I. E., Davies, D. P., Harran, M. J. andHughes, C. A. (1979) The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small intestine of the human neonate.In Development of mammalian absorptive processes,Elliott, K. andWhelan, J. (Eds.), Ciba Foundation Symposium No. 70. Excerpta Medica, Amsterdam, 267–276.Google Scholar
  6. Read, N. W., Holdsworth, C. D. andLevin, R. J. (1974) Electrical measurement of intestinal absorption of glucose in man.Lancet,2, 624–627.CrossRefGoogle Scholar
  7. Read, N. W., Levin, R. J. andHoldsworth, C. D. (1976) Electrogenic glucose absorption in untreated and treated coeliac disease.Gut,17, 444–449.Google Scholar
  8. Sachar, D. B., Taylor, J. O., Saha, J. R. andPhillips, R. A. (1969) Intestinal transmural electric potential and its response to glucose in acute and convalescent cholera.Gastroenterology,56, 512–521.Google Scholar
  9. Wingate, D., Green, R., Symes, J. andPilot, M. (1974) Interpretation of fluctuations of transmural potential difference across the proximal small intestine.Gut,15, 515–520.Google Scholar

Copyright information

© IFMBE 1982

Authors and Affiliations

  • G. C. Aucott
    • 1
  • D. A. Ducker
    • 2
  • A. S. McNeish
    • 2
  1. 1.Department of Medical PhysicsLeicester Royal InfirmaryLeicesterUK
  2. 2.Department of Child HealthUniversity of Leicester Medical SchoolLeicesterUK

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