Medical and Biological Engineering and Computing

, Volume 18, Issue 6, pp 741–745 | Cite as

Application of catheter-tip i.s.f.e.t. for continuousin vivo measurement

  • K. Shimada
  • M. Yano
  • K. Shibatani
  • Y. Komoto
  • M. Esashi
  • T. Matsuo
Article

Abstract

A catheter-tip pH sensor was developed for possible clinical and biomedical application, using an ion-sensitive field-effect transistor (i.s.f.e.t.). Its signal drift in buffer solutions during continuous measurement was less than 3 mV in 24 h (equivalent to about 0·05 pH in 24 h). The electric insulation was perfect when soaked in buffer solutions for more than 3 months. A continuousin vivo pH measurement was successfully achieved in nonheparinised arterial blood of a japanese monkey. There was no significant sign of clot formation for 8 hours. It revealed quick responses to respiratory acidosis and alkalosis, and the observed pH values were in accordance with those confirmed by a blood pH analyser. Also, a catheter-tip pCO2 sensor was prepared, using the catheter-tip pH i.s.f.e.t. The response time was 2 min for a 90% change in CO2 tension. The muscle pCO2 monitoring tested with it indicated a similar result to those with medical mass spectrometer.

Keywords

Blood monitoring Catheter-tip pH sensor I.S.F.E.T. Miniature pH sensor Miniature pCO2 sensor 

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References

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Copyright information

© IFMBE 1980

Authors and Affiliations

  • K. Shimada
    • 1
  • M. Yano
    • 1
  • K. Shibatani
    • 1
  • Y. Komoto
    • 2
  • M. Esashi
    • 3
  • T. Matsuo
    • 3
  1. 1.Central Research LaboratoriesKuraray Co. Ltd.Kurashiki, OkayamaJapan
  2. 2.Department of Surgery, Institute of Thermal Spring ResearchOkayama UniversityTottoriJapan
  3. 3.Department of Electric Engineering Tohoku UniversitySendai MiyagiJapan

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