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A high-resolution interval timer and buffered storage system for neurophysiological experiments

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Abstract

A high-resolution interval timer, designed as a computer peripheral for use in neurophysiological experiments, is described. With only minimal intervention by the controlling computer, this device detects, identifies and times the occurrence of discriminated neuronal discharges and changes in experimental status, and autonomously stores these encoded times in an on-board 4K×16 r.a.m. This device reduces the need for detailed software timing routines, while still permitting user selectible resolution (>1 to <100 μs/bit) and asynchronous access to the stored data by the controlling computer. The flexibility of this device and its ability to collect data autonomously make it extremely useful in a wide variety of sensory and behavioural neurophysiological experiments.

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References

  • Arnett, D. W. andEllert, B. M. (1976) Real-time cross-correlator for neurophysiological research.IEEE Trans. Biomed. Eng.,23, 65–70.

    Google Scholar 

  • Bak, M. J. andSchmidt, E. M. (1977) An analogue delay circuit for online visual confirmation of discriminated neuroelectric signals.IEEE Trans. Biomed. Eng.,24, 69–71.

    Google Scholar 

  • Byrne, J. (1975) A feedback controlled stimulator that delivers controlled displacements or forces to cutaneous mechanoreceptors.IEEE Trans. Biomed. Eng.,22, 66–69.

    Google Scholar 

  • Daigle, R. E., Morgan, R. J. andBudak, A. (1973) Window discrimination using integrated circuits.IEEE Trans. Biomed. Eng.,20, 303–306.

    Google Scholar 

  • Ekstedt, J. andStalberg, E. (1970) Electronic time interval measurements, data logging on magnetic tape and computer data analysis in single fiber electromyography.Comput. Programs Biomed.,1, 119–133.

    Article  Google Scholar 

  • French, A. S. (1973) Automated spectral analysis of neurophysiological data using intermediate magnetic tape storage.Comput. Programs Biomed.,3, 45–57.

    Article  Google Scholar 

  • French, A. S. (1970) Online storage of event/time data using a magnetic disc unit.Comput. Programs Biomed.,1, 134–145.

    Article  Google Scholar 

  • French, A. S. andHolden, A. V. (1971a) Frequency domain analysis of neurophysiological data.Comput. Programs Biomed.,1, 219–234.

    Article  Google Scholar 

  • French, A. S. andHolden, A. V. (1971b) Semionline implementation of analysis-free sampling system for neuronal signals.Comput. Programs Biomed.,2, 1–7.

    Article  Google Scholar 

  • Gagne, S. andPoussart, D. (1976) Instantaneous frequency measurements of neural events: Application of nonuniformly distributed RC line.IEEE Trans Biomed. Eng.,23, 16–22.

    Google Scholar 

  • Giard, M. H., Pernier, J., Bailly, G. andRubel, P. (1978) Analyseur de responses neuronales a base de microprocesseur.Med. & Biol. Eng. & Comput.,16, 425–428.

    Google Scholar 

  • Glaser, E. M. andRuchkin, D. S. (1976)Principles of neurobiological signal analysis, Chapter 6, Academic Press, New York.

    Google Scholar 

  • Hoffman, R. A., Painter, J. P. andLong, D. D. (1977) A transient recorder/digitiser for biomedical applicationsIEEE Trans. Biomed. Eng.,24, 193–195.

    Google Scholar 

  • Hunt, C. C. (1974) The Pacinian corpuscle.In Hubbard, J. I. (Ed.)The peripheral nervous system, pp. 405–420, Plenum Press, London.

    Google Scholar 

  • Monro, D. M. (1978) Continuous data acquisition at maximum rates.Comput. Programs Biomed.,8, 91–98.

    Article  Google Scholar 

  • Poggio, G. F. andMountcastle, V. B. (1963). The functional properties of ventrobasal thalamic neurons studied in unanesthetised monkeys.J. Neurophysiol.,26, 775–806.

    Google Scholar 

  • Robinson, C. J. (1979a) R.A.M.-I.T.: a high-resolution interval timer and buffered storage system for neurophysiological experiments.In Ostrander, L. E. (Ed.)Proceedings of the Seventh Annual New England (Northeast) Bioengineering Conference, Troy, New York. March 22–23, pp. 5–8.

  • Robinson, C. J. (1979b) An electrophysiological investigation of somatically-activated neurons in the primate second somatosensory area (SII) and in neighbouring cortical fields. DSc Thesis, Washington University, St. Louis, Mo.

    Google Scholar 

  • Sass, D. J. (1977) Time, date and event code generator to identify physiological events simultaneously recorded on magnetic tape and oscillographic paper.IEEE Trans. Biomed. Eng.,24, 425–429.

    Google Scholar 

  • Schmidt, E. M. (1971) An instrument for separation of multiple-unit neuroelectric signals.IEEE Trans. Biomed Eng.,18, 155–157.

    Google Scholar 

  • Stagg, D. (1973) Computer acquisition of multiunit nerve spike signals.Med. & Biol. Eng.,11, 340–347.

    Google Scholar 

  • Talbot, W. H. (1973) Use of a laboratory digital computer in the single-unit analysis of sensory systems. InWeiss, B. (Ed.)Digital computer in the behavioral laboratory, Chapter 7, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Wall, P. D. (1959) Repetitive discharge of neurons.J. Neurophysiol.,22, 305–320.

    Google Scholar 

  • Wyss, U.R. (1970) STAP-8: a subroutine package for statistical online analysis of simultaneous neuronal spiketrains.Comput. Programs Biomed.,1, 9–22.

    Article  Google Scholar 

  • Wyss, U. R. andHandwerker, H. (1971) STAP-12: a library system for online assimilation and offline analysis of event/time data.

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Robinson, C.J., Burton, H. A high-resolution interval timer and buffered storage system for neurophysiological experiments. Med. Biol. Eng. Comput. 18, 731–740 (1980). https://doi.org/10.1007/BF02441898

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  • DOI: https://doi.org/10.1007/BF02441898

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