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High-quality recording of bioelectric events

Part 2 Low-noise, low-power multichannel amplifier design

Abstract

A multichannel instrumentation amplifier, developed to be used in a miniature universal eight-channel amplifier module, is described. After discussing the specific properties of a bioelectric recording, the difficulties of meeting the demanded specifications with a design based on operational amplifiers are reviewed. Because it proved impossible to achieve the demanded combination of low noise and low power consumption using commercially available operational amplifiers, an amplifier equipped with an input stage with discrete transistors was developed. A new design concept was used to expand the design to a multichannel version with an equivalent input noise voltage of 0·35 μV RMS in a bandwidth of 0·1–100 Hz and a power consumption of 0·6 mW per channel. The results of this study are applied to miniature, universal, eight-channel amplifier modules, manufactured with thick-film production techniques. The modules can be coupled to satisfy the demand for a multiple of eight channels. The low power consumption enables the modules to be used in all kinds of portable and telemetry measurement systems and simplifies the power supply in stationary measurement systems.

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References

  • Almasi, J. J. andSchmitt, O. H. (1970) Systemic and random variations of ECG electrode impedance.Ann. NY Acad. Sci.,170, 509–519.

    Google Scholar 

  • Clark, J. W. (1978) The origin of biopotentials. InMedical instrumentation: application and design.Webster, J. G. (Ed.), Houghton Mifflin Co., Boston, 184–207.

    Google Scholar 

  • Cooper, R., Osselton, J. W. andShaw, J. C. (1969)EEG technology. Butterworth, London, 14–22.

    Google Scholar 

  • Duff, T. A. (1980) Topography of scalp recorded potentials by stimulation of the digits.Electroenceph. Clin. Neurophysiol.,49, 452–460.

    Article  Google Scholar 

  • Duffy, F. H. (1982) Topographic display of evoked potentials: clinical applications of brain electrical activity mapping (BEAM). Evoked potentials.Ann. NY Acad. Sci.,388, 183–196.

    Google Scholar 

  • Geddes, L. A. (1972)Electrodes and the measurements of bioelectric events. John Wiley & Sons, New York, 44–94.

    Google Scholar 

  • Geddes, L. A. andBaker, L. E. (1989)Principles of applied biomedical instrumentation, 3rd edn. John Wiley & Sons, New York, 677–743.

    Google Scholar 

  • Graeme, J. G. (1977)Designing with operational amplifiers: application alternatives. McGraw-Hill, New York, 31–35.

    Google Scholar 

  • Grimnes, S. (1983) Impedance measurement of individual skin surface electrodes.Med. & Biol. Eng. & Comput.,21, 750–755.

    Article  Google Scholar 

  • Gruzelier, J. D., Liddiard, D., Davis, L. andWilson, L. (1988) Topographic mapping of electrocortical activity in schizophrenia during directed nonfocussed attention recognition memory and motor programming. InFunctional brain imaging.Pfurtscheller, G. andLopez da Silva, F. H. (Eds.), Hans Huber Publishers Inc., Lewiston, New York, 181–186.

    Google Scholar 

  • Hamstra, G. H., Peper, A. andGrimbergen, C. A. (1984) Low-power, low-noise instrumentation amplifier for physiological signals.Med. & Biol. Eng. & Comput.,22, 272–274.

    Article  Google Scholar 

  • Huhta, J. C. andWebster, J. G. (1973) 60-Hz interference in electro-cardiography.IEEE Trans.,BME-20, 91–101.

    Google Scholar 

  • Metting van Rijn, A. C., Peper, A. andGrimbergen, C. A. (1990) High-quality recording of bioelectric events. Part 1 Interference reduction, theory and practice.Med. & Biol. Eng. & Comput.,28, 389–397.

    Google Scholar 

  • Morrison, R. (1977)Grounding and shielding techniques in instrumentation. John Wiley & Sons, New York, 132–133.

    Google Scholar 

  • Motchenbacher, C. D. andFitchen, F. C. (1972)Low-noise electronic design. John Wiley & Sons, New York, 37–38,182, 206–216.

    Google Scholar 

  • Nelson, C. T. (1980) Supermatched bipolar transistors improve DC and AC designs.EDN, 5th Jan., 115–120.

  • O'Brien, M. J., van Eykern, L. A. andPrechtl, H. F. R. (1983) Monitoring respiratory activity in infants, a non intrusive diaphragm EMG technique. InNon-invasive measurements: 2.Rolfe, P. (Ed.), Academic Press, London, 131–177.

    Google Scholar 

  • Pacela, A. F. (1967) Collecting the body's signals.Electronics,40, (14), 103–112.

    Google Scholar 

  • Reek, E. J., Grimbergen, C. A. andvan Oosterom, A. (1984) A low-cost 64 channel microcomputer based data acquisition system for bedside registration of body surface maps. Proc. 11th Int. Congr. Electrocardiol., Caen, France, 17th–20th July, 37–38.

  • Rosell, J., Colominas, J., Riu, P., Pallas-Areny, R. andWebster, J. G. (1988) Skin impedance from 1 Hz to 1 MHz.IEEE Trans.,BME-35, 649–651.

    Google Scholar 

  • Sergent, J. E. (1981) Understanding the basics of thick-film technology.EDN, 14th Oct., 341–349.

  • Silverman, D., Masland, R. L., Saunders, M. G. andSchwab, R. S. (1969) Minimal electroencephalographic recording techniques in suspected cerebral death.Electroenceph. Clin. Neurophysiol.,29, 731–732.

    Google Scholar 

  • Smit, H. W., Verton, K. andGrimbergen, C. A. (1987) A low-cost multichannel preamplifier for physiological signals.IEEE Trans.,BME-34, 307–310.

    Google Scholar 

  • Spekhorst, H. andSippensGroenewegen, A. (1990) Body surface mapping during percutaneous transluminal coronary angioplasty: QRS changes indicating regional conduction delay.Circ.,81, 840–849.

    Google Scholar 

  • Tobey, G. E., Graeme, J. G. andHuelsman, L. P. (1971)Operational amplifiers: design and applications. McGraw-Hill, New York, 205–207.

    Google Scholar 

  • Wilson, N. F., Johnston, F. E., Macleod, A. G. andBarker, P. S. (1934) Electrocardiograms that represent the potential variations of a single electrode.Am. Heart J.,9, 447–458.

    Article  Google Scholar 

  • Winter, B. B. andWebster, J. G. (1983) Driven-right-leg circuit design.IEEE Trans.,BME-30, 62–66.

    Google Scholar 

  • Wong, Y. G. andOtt, W. E. (1976)Functional circuits: design and applications. McGraw-Hill, New York, 42–45.

    Google Scholar 

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Metting van Rijn, A.C., Peper, A. & Grimbergen, C.A. High-quality recording of bioelectric events. Med. Biol. Eng. Comput. 29, 433–440 (1991). https://doi.org/10.1007/BF02441666

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  • DOI: https://doi.org/10.1007/BF02441666

Keywords

  • Bioelectric recordings
  • Low noise
  • Low power consumption
  • Multichannel front end
  • Small dimensions