Summary
Fifty adult female rats were used to study the effect of 1-alpha-hydroxyvitamin D3 (1α-OH-D3)on bone after oophorectomy. The experimental period was 6 months. At the end of the experiment the femurs and the tibias were investigated for bone mass and composition. Significant signs of osteopenia occurred as a result of oophorectomy. The treatment with 1α-OH-D3 induced only minor changes in blood chemistry but increased bone mass significantly. The findings support the view that 1α-OH-D3 may be a valuable tool in the treatment of osteoporosis resulting from ovarian insufficiency.
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References
Albright, F., Smith, P.H., Richardson, A.M.: Post-menopausal osteoporosis: its clinical features, JAMA116:2465–2474, 1941
Heaney, R.P.: Estrogens and postmenopausal osteoporosis, Clin. Obstet. Gynecol.19:791–803, 1976
DeLuca, H.F.: Vitamin D metabolism, Clin. Endocrinol. [Suppl.]7:1–17, 1977
Reynolds, J.J., Holick, M.F., DeLuca, H.F.: The effects of vitamin D analogues on bone resorption, Calcif. Tissue Res.15:333–339, 1974
Lindholm, T.S., Sevastikoglou, J.A., Lindgren, J.U.: Treatment of patients with senile, postmenopausal and corticosteroid-induced osteoporosis with 1α-hydroxy vitamin D3 and calcium: short- and long-term effects, Clin. Endocrinol. [Suppl.]7:183–189, 1977
Saville, P.D.: Changes in skeletal mass and fragility with castration in the rat: a model of osteoporosis, J. Am. Geriatr. Soc.17:155–166, 1969
Mueller, K., Trias, A., Ray, R.D.: Bone density and composition, J. Bone Joint Surg.48-A:138–148, 1966
Barnett, E., Nordin, B.E.C.: The radiological diagnosis of osteoporosis: a new approach, Clin. Radiol.11:166–174, 1960
Robinson, R.A., Elliot, S.R.: The water content of bone, J. Bone Joint Surg.39-A:167–188, 1957
Snedecor, G.W., Cochran, W.G.: Statistical Methods. Iowa State University Press, Ames, Iowa, 1967
Bohr, H.: On the calcium metabolism and growth rate of rats, Calcif. Tissue Res. [Suppl.]2:68, (1968) (abstr.)
Aitken, J.M., Armstrong, E., Anderson, J.B.: Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and/or progestrogen replacement therapy in its prevention, J. Endocrinol.55:79–87, 1972
Larsson, S.E., Ahlgren, O.: The role of the parathyroids for the adaptation to a low calcium intake, Acta Path. Microbiol. Scand.83A:13–24, 1975
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Lindgren, J.U., Lindholm, T.S. Effect of 1-alpha-hydroxyvitamin D3 on osteoporosis in rats induced by oophorectomy. Calcif Tissue Int 27, 161–164 (1979). https://doi.org/10.1007/BF02441179
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DOI: https://doi.org/10.1007/BF02441179