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Calcified Tissue International

, Volume 27, Issue 1, pp 127–128 | Cite as

Effect of lithium on parathyroid hormone-induced calcium release from bone rudiments

  • Daniel T. Baran
  • James K. Burks
  • Catherine A. Richardson
  • Joan B. Hamilton
  • Linda R. Halstead
  • T. J. Hahn
  • Steven L. Teitelbaum
  • Louis V. Avioli
Laboratory Investigations

Summary

Lithium treatment of humans and animals has been associated with adverse effects on bone and mineral metabolism. In order to determine whether lithium was altering the skeletal response to parathyroid hormone, we incubated bone rudiments for 5 days in the presence or absence of the drugs. Lithium had no effect on either parathyroid hormone-induced cyclic AMP generation or45Ca release from the bone rudiments. The data are consistent with the hypothesis that the skeletal effects of lithium are not mediated via inhibition of the parathyroid hormone-adenyl cyclase-cyclic AMP system.

Key words

Lithium Parathyroid hormone Bone rudiments 

References

  1. 1.
    Christiansen, C., Baastrup, P.C., Transbol, I.L.: Lithium-induced “primary” hyperparathyroidism, Calcif. Tissue Res.22:341–343, 1976CrossRefGoogle Scholar
  2. 2.
    Baran, D.T., Schwartz, M.P., Bergfeld, M.A., Slatopolsky, E., Teitelbaum, S.L., Avioli, L.V.: Lithium inhibition of bone mineralization and osteoid formation. J. Clin. Invest.61:1691–1696, 1978PubMedGoogle Scholar
  3. 3.
    Raisz, L.G., Niemann, I.: Effect of phosphate calcium and magnesium on bone resorption and hormonal response in tissue culture, Endocrinology85:446–452, 1969PubMedGoogle Scholar
  4. 4.
    Hahn, T.J., Scharp, C.R., Richardson, C.A., Halstead, L.R., Kahn, A.J., Teitelbaum, S.L.: Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorptionin vitro, J. Clin. Invest.62:406–414, 1978PubMedGoogle Scholar
  5. 5.
    Singer, I., Rotenberg, D., Puschett, J.B.: Lithium-induced nephrogenic diabetes insipidus:in vivo andin vitro studies, J. Clin. Invest.51:1081–1091, 1972PubMedGoogle Scholar
  6. 6.
    Forrest, J.N., Jr., Cohen, A.D., Torrett, J., Himmelhoch, J.M., Epstein, F.H.: On the mechanism of lithium-induced diabetes insipidus in man and the rat, J. Clin. Invest.53:1115–1123, 1974PubMedCrossRefGoogle Scholar
  7. 7.
    Emerson, C.H., Dyson, W.L., Higer, R.D.: Serum thyrotropin and thyroxine concentrations in patients receiving lithium carbonate, J. Clin. Endocrinol. Metab.36:338–346, 1973PubMedGoogle Scholar
  8. 8.
    Dousa, T., Hechter, O.: The effect of NaCl and LiCl on vasopressin-sensitive adenyl cyclase, Life Sci.9:765–770, 1970CrossRefGoogle Scholar
  9. 9.
    Forrest, J.N., Jr.: Lithium inhibition of cAMP-mediated hormones: a caution, N. Engl. J. Med.292:423–424, 1975PubMedCrossRefGoogle Scholar
  10. 10.
    Baran, D.T., Burks, J.K., Hahn, T.J., Avioli, L.V.: Effect of lithium on calcium release and cyclic AMP generation from bonein vitro, Clin. Res.25:521A, 1977Google Scholar
  11. 11.
    Spiegel, A.M., Gerner, R.H., Murphy, D.L., Aurbach, G.D.: Lithium does not inhibit the parathyroid hormone-mediated rise in urinary cyclic AMP and phosphate in humans, J. Clin. Endocrinol. Metab.43:1390–1393, 1976PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Daniel T. Baran
    • 1
  • James K. Burks
    • 1
  • Catherine A. Richardson
    • 1
  • Joan B. Hamilton
    • 1
  • Linda R. Halstead
    • 1
  • T. J. Hahn
    • 1
  • Steven L. Teitelbaum
    • 1
  • Louis V. Avioli
    • 1
  1. 1.Division of Bone and Mineral Metabolism and the Department of PathologyJewish Hospital of St. Louis and Washington UniversitySt. Louis

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