Summary
The perilacunar areas of low mineral density in microradiographs from cortical bone of patients with hypophosphatemic (vitamin D-resistant) rickets are not evenly distributed throughout the bone tissue. Their frequency and distribution were determined in bone from 9 patients with this disease. It was found that the lesion was more frequent in haversian bone than in interstitial bone, and along the inner circumference of growing haversian systems as compared with the outer circumference. These findings indicate that the lesion is the result of retarded mineralization, and that mineralization slowly proceeds in these areas as the bone becomes older. A relatively high frequency of the lesion was also found in osteons with an elliptical cross section along the long axis of the ellipse. The cause of the abundance of the lesion at these sites is not clear, but it is possible to explain the uneven distribution in elliptical osteons by assuming an unequal rate of bone formation in these structures.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Frost, H.M.: A unique histological feature of vitamin D-resistant rickets observed in four cases, Acta Orthop. Scand.33:220–226, 1963
Steendijk, R., Jowsey, J., van den Hooff, A., Nielsen, H.K.L.: Microradiographic and histological observations in primary vitamin D-resistant rickets. In H. Fleisch, H.J.J. Blackwood, M. Owen (eds.): Calcified Tissues 1965, Proceedings of the Third European Symposium, pp. 175–178. Springer, Berlin, 1966
Adams, P.H., Jowsey, J.: Sodium fluoride in the treatment of osteoporosis and other bone diseases, Ann. Intern. Med.63:1151–1155, 1965
Baud, C.A., Boivin, G.: Modifications of the perilacunar wall resulting from the effect of fluoride on osteocytic activity, Metab. Bone Dis. Rel. Res.1:49–54, 1978
Steendijk, R., Boyde, A.: Scanning electron microscopic observations on bone from patients with hypophosphatemic (vitamin D-resistant) rickets, Calcif. Tissue Res.11:242–250, 1973
Buss, R.O., Frost, H.M.: The prevalence of halo volume in familial vitamin D-resistant rickets, Calc. Tissue Res. 7:76–80, 1963
Jowsey, J., Gershon-Cohen, J.: Clinical and experimental osteoporosis. In H.J.J. Blackwood (ed.): Bone and Tooth, Proceedings of the First European Symposium, pp. 35–48. Pergamon Press, Oxford, 1969
Sachs, L.: Statistische Auswertungsmethoden, 2nd Ed., pp. 343–345, Springer, Berlin, 1969
Frost, H.M. The dynamics of human osteoid tissue. In D.J. Hioco (ed.): l'Ostéomalacie, pp. 3–18. Masson & Cie, Paris, 1967
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Choufoer, J.H., Steendijk, R. Distribution of the perilacunar hypomineralized areas in cortical bone from patients with familial hypophosphatemic (vitamin D-resistant) rickets. Calcif Tissue Int 27, 101–104 (1979). https://doi.org/10.1007/BF02441169
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02441169