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Uptake of47Ca into the forearm in normal subjects and in patients with osteomalacia, primary biliary cirrhosis, and hyperparathyroidism

  • R. C. Smart
  • C. D. Holdsworth
Clinical Investigations
  • 18 Downloads

Summary

The rate of accumulation of47Ca in the tissues of the forearm in the 24 h following an intravenous bolus injection of 2 µCi of47CaCl2 was monitored using a large-volume scintillation counter and analyzed using principal component analysis. In normal subjects activity rose rapidly to a maximum value of about 2% of the administered dose between 2 and 4 h after injection, and had declined little if at all after 24 h. The first three principal components of the uptake curves accounted for a cumulative total of 99.4% of the variance of the data. The eight patients with osteomalacia had a significantly positive weighting factor for the first component, which reflected relatively rapid uptake 15 min after injection and increased total uptake at 6 h. The 6 patients with primary biliary cirrhosis but no overt bone disease had a less marked abnormality which probably represented early osteomalacia. The 3 patients with hyperparathyroidism had normal rates of uptake. Principal component analysis made it possible to quantitate differences in the rate of calcium uptake by the forearm tissues under varying physiological conditions without the need for assumptions on compartmental distribution.

Key words

47Ca isotope Calcium kinetics Osteomalacia Primary biliary cirrhosis Hyperparathyroidism 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • R. C. Smart
    • 1
  • C. D. Holdsworth
    • 1
  1. 1.Departments of Medical Physics and MedicineHallamshire HospitalSheffieldEngland

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