European Journal of Clinical Pharmacology

, Volume 44, Issue 6, pp 579–582 | Cite as

On the bioavailability of 2-chloro-2-deoxyadenosine (CdA)

The influence of food and omeprazole
  • F. Albertioni
  • G. Juliusson
  • J. Liliemark
Originals

Summary

The pharmacokinetics of oral CdA (0.24 mg/kg) was studied in 4 patients (1 with hairy cell leukaemia and 3 with B-cell chronic lymphocytic leukaemia) to determine any effect of food and fasting with and without omeprazole.

Food intake did not significantly influence the bioavailability of CdA (42% after food intake vs 46% while fasting) but it did reduce the maximum plasma concentration (Cmax) by 40%; 83 compared to 116 nM while fasting. The time to reach maximum concentration (tmax) was delayed about 0.8 h after food intake. Pretreatment with omeprazole did not significantly influence the bioavailability of CdA (51% vs 46% without), or the interindividual variability in bioavailability in the fasting state (C.V. 0.26 with and C.V. 0.27 without).

In conclusion, there was a small, though not statistically significant reduction in the bioavailability of CdA after food intake. Omeprazole did not significantly improve the bioavailability of CdA.

Key words

2-Chloro-2-deoxyadenosine (CdA) omeprazole food pharmacokinetics bioavailability 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • F. Albertioni
    • 1
  • G. Juliusson
    • 2
  • J. Liliemark
    • 1
    • 2
  1. 1.Department of Clinical PharmacologyKarolinska HospitalStockholmSweden
  2. 2.Division of Clinical Hematology and Oncology, Department of MedicineKarolinska Institute at Huddinge HospitalHuddingeSweden

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