European Journal of Clinical Pharmacology

, Volume 44, Issue 6, pp 529–533 | Cite as

Memory and psychomotor effects of oxcarbazepine in healthy human volunteers

  • H. V. Curran
  • R. Java
Originals

Summary

Cognitive and psychomotor impairments can be unwanted adverse effects of antiepileptic drugs. The present double-blind, coross-over study with healthy volunteers was designed to assess the effects of two doses of oxcarbazepine (OXCZ) (150 mg b.i.d.; 300 mg b.i.d.) and a placebo, each given over a two week period. Twelve subjects completed a battery of tests before and 4 h after morning doses on days 1,8 and 15.

Results of objective tests indicated that OXCZ improved performance on a focussed attention task and increased manual writing speed. Subjective ratings showed OXCZ increased feelings of altertness, clear-headedness and quickwittedness. OXCZ had no effect on the range of long-term memory processes assessed in this study. It is concluded that at the doses employed, OXCZ has a slightly stimulant effect on some aspects of psychomotor functioning.

Key words

Oxcarbazepine Psychomotor function antiepileptic drug memory 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen D, Curran HV, Lader M (1991) The effects of repeated doses of clomipramine and alprazolam on physiological, psychomotor and cognitive functions in normal subjects. Eur J Clin Pharmacol 40:355–362PubMedCrossRefGoogle Scholar
  2. Baddeley AD (1968) A 3 minute reasoning test based on grammatical transformation. Psychon Sci 10:341–342Google Scholar
  3. Battig WF, Mongtague WE (1969) Category norms for verbal items in 56 categories: a replication and extension of the Connecticut Category Norms. J Exper Psychol 80:1–46CrossRefGoogle Scholar
  4. Bond AJ, Lader MH (1972) Residual effects of hypnotics. Psychopharmacologia 25:117–132PubMedCrossRefGoogle Scholar
  5. Bond AJ, Lader MH (1974) The use of analogue scales in rating subjective feedings. Brit J Med Psychol 47:211–218Google Scholar
  6. Bulan P, Frosher W (1991) Oxcarbazepine as a new antiepileptic substance. Drugs Today 27:51–54Google Scholar
  7. Curran HV, Schiwy W, Lader MH (1987) Differential amnesic properties of benzodiazepines: a dose-response comparison of two drugs with similar elimination half-lives. Psychopharmacol 92:358–364CrossRefGoogle Scholar
  8. Curran HV, Allen D, Lader MH (1987) The effects of single doses of alpidem and lorazepam on memory and psychomotor performance of normal humans. J Psychopharmacol 1:81–89Google Scholar
  9. Curran HV, Schiffano F, Lader MH (1991) Models of memory dysfunction? A comparison of the effects of scopolamine and lorazepam on memory, psychomotor performance and mood. Psychopharmacol 103:83–90CrossRefGoogle Scholar
  10. Curran HV, Sakulsripong MQ, Lader M (1988) Antidepressants and memory: an investigation of four drugs with different sedative and anticholinergic profiles. Psychopharmacol 95:520–527Google Scholar
  11. Dam M (1987) Oxcarbazepine. In: Dam M (ed) Epilepsy: progress in treatment. Wiley, New York, pp 257–261Google Scholar
  12. Dam M (1990) Oxcarbazepine in monotherapy. Behav Neurol 3 [Suppl 1]:31–34Google Scholar
  13. Dodrill CB (1988) Effects of antiepileptic drugs on abilities. J Clin Psychiatry 49:31–34PubMedGoogle Scholar
  14. Dodrill CB, Troupin AS (1991) Neuropsychological effects of carbamazepine and phenytoin: a reanalysis. Neurology 41:141–143PubMedGoogle Scholar
  15. Frith CD (1967) The effects of nicotine on tapping. Life Sci 6:321–326PubMedCrossRefGoogle Scholar
  16. Houtkooper MA, Lammertsma A, Meyer JWA, Goedhart DM, Meinardi H, van Oorschot CAEH, Bloom GF, Hoppener RJEA, Hulsman JARJ (1987) Oxcarbazepine (GP 47.680): a possible alternative to carbamazepine? Epilepsia 28:693–698PubMedGoogle Scholar
  17. Meador KJ, Loring DW, Huh K, Gallagher BB, King DW (1990) Comparative cognitive effects of anticonvulsants. Neurology 40: 391–394PubMedGoogle Scholar
  18. Mondadori C, Classen W (1984) The effects of various antiepileptic drugs on E-shock induced amnesia in mice: dissociability of effects on convulsions and effects on memory. Acta Neurol Scand 69 (S99):125–129CrossRefGoogle Scholar
  19. Sakulsripong MQ, Curran, HV, Lader MH (1991) Does tolerance develop to the sedative and amnesic effects of antidepressants? A comparison of amitriptyline, trazodone and placebo. Eur J Clin Pharmacol 40:43–48PubMedCrossRefGoogle Scholar
  20. Shepherd RN, Mezler J (1971) Mental rotation of three-dimensional objects. Science 171:701–703Google Scholar
  21. Trimble MR (1987) Anticonvulsant drugs and cognitive function: a review of the literature. Epilepsia 28:S37-S45PubMedGoogle Scholar
  22. Wechsler D (1955) Manual for the Wechsler Adult Intelligence Scale. Psychological Corporation, New YorkGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. V. Curran
    • 1
  • R. Java
    • 1
  1. 1.Department of PsychiatryInstitute of PsychiatryLondonUK

Personalised recommendations