The effects of acetylsalicylic acid on phosphoenolpyruvate carboxykinase activity and acinar heterotopy in livers from juvenile and adult rats
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Male and female juvenile as well as adult rats were treated with acetylsalicilic acid in order to examine the effect of the drug on over-all activity and activity distribution of phosphoenolpyruvate carboxykinase (PEPCK) in the liver acinus. Upon administration of acetylsalicilic acid PEPCK activity increased in juvenile males and adult females, but was reduced in juvenile females and adult males. The periportal-perivenous activity gradient along the sinusoidal length, which is flatter in untreated juvenile rats compared to the livers of adult rats, was distinctly steepened by acetylsalicilic acid treatment. Acetylsalicilic acid did not affect the gradient in adult rats.
KeywordsPyruvate Kinase Silymarin Phosphoenolpyruvate Carboxykinase Juvenile Female Treated Male
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