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Review: A comparative analysis of studies of enzyme changes with age, with comments on possible sources of error

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Abstract

Studies on enzyme changes during aging from rodents, nematodes and tissue culture cells have been reviewed. In the rodent and tissue culture studies, conflicting results on aging of specific enzymes have been reported from several laboratories. These works have been analyzed, with the aim of stressing the different findings and analyzing possible reasons for the discrepancies. With regard to the nematode studies, the authors suggest that the examination of the concept of general failure of protein synthesis mechanisms as a basic cause of cellular senescence requires more rigorous methods than have been utilized in previous studies.

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Authors and Affiliations

  1. Institut für Biochemie I die Universität Heidelberg, Heidelberg, Germany

    Heinrich F. Klefenz

  2. Laboratory of Experimental Biology, University of Massachusetts, East Wareham, Massachusetts, 02538

    Bert M. Zuckerman

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  1. Heinrich F. Klefenz
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  2. Bert M. Zuckerman
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Klefenz, H.F., Zuckerman, B.M. Review: A comparative analysis of studies of enzyme changes with age, with comments on possible sources of error. AGE 1, 60–67 (1978). https://doi.org/10.1007/BF02439876

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  • DOI: https://doi.org/10.1007/BF02439876

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