, Volume 1, Issue 2, pp 50–55 | Cite as

A study of axonal degeneration in the optic nerves of aging mice

  • John E. JohnsonJr.
  • D. E. Philpott
  • Jaime Miquel


The optic nerves of C57BL/6J mice ranging from 3 to 30 months were examined by electron microscopy. At all ages investigated, optic nerve axons contained enlarged mitochondria with abnormal cristae. With increasing age, a large number of necrotic axons were observed and were in the process of being phagocytized. The abnormal mitochondria may represent preliminary changes that eventually lead to necrosis of the axon.


Electron Microscopy Optic Nerve Aging Mouse Axonal Degeneration Nerve Axon 
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Copyright information

© American Aging Association, Inc. 1978

Authors and Affiliations

  • John E. JohnsonJr.
    • 1
  • D. E. Philpott
    • 1
  • Jaime Miquel
    • 1
  1. 1.Biomedical Research DivisionNASA Ames Research CenterMoffett Field

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