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Age related changes in fluorescence and respiratory properties of liver mitochondria

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Fluorescence and respiratory properties of rat liver mitochondrial membranes in young and old animals have been measured. A trend toward decreasing specific activity of malate + glutamate supported state 4 respiration in mitochondria from 18 month old animals as compared to 1 month old animals is found. A concomitant decrease in membrane protein tryptophane fluorescence and an increase in a membrane fluorophore proposed to be aminoiminopropene has also been observed using nanosecond fluorescence spectroscopy techniques.

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Authors and Affiliations

  1. Department of Physics, Indiana State University, USA

    Torsten Alvager

  2. Department of Chemistry, Indiana State University, USA

    Walter X. Balcavage

  3. Terre Haute Center for Medical Education and Department of Biochemistry, Indiana University School of Medicine, Terre Haute, Indiana, 47809

    Walter X. Balcavage

Authors
  1. Torsten Alvager
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  2. Walter X. Balcavage
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Alvager, T., Balcavage, W.X. Age related changes in fluorescence and respiratory properties of liver mitochondria. AGE 1, 42–48 (1978). https://doi.org/10.1007/BF02439873

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  • DOI: https://doi.org/10.1007/BF02439873

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