Collagenolytic protease preparations from invertebrates: Experimental study of acute and chronic toxicity

  • B. A. Paramonov
  • O. A. Klimova
  • V. Yu. Chebotarev
Pharmacology and Toxicology


Toxicity of active matter of new structure-destroying enzyme preparations containing a complex of collagenolytic proteases from invertebrates (Collagenase from hydrobionts, Polycollagenase-K, Fermenkol) was studied. The absence of acute toxicity in skin application is proved, and LD50 for intraperitoneal administration to mice and rats were determined. A long-term treatment with clinical doses under various types of application does not affect body weight gain, biochemical indices of the plasma, ECG, diuresis, and urine content.

Key words

enzyme preparations collagenolytic proteases acute toxicity chronic toxicity 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • B. A. Paramonov
    • 1
  • O. A. Klimova
    • 1
  • V. Yu. Chebotarev
    • 1
  1. 1.St. Petersburg-TechnologiyaSt. Petersburg

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