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Studies of bronchoalveolar lavage in sudden infant death syndrome: A clinical-pathological study

  • Pediatric Ear, Nose, Throat Disorders
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Abstract

The incidence of sudden infant death syndrome (SIDS) in Hungary was 0.3 per 1000 live births in 1992. We investigated bronchoalveolar lavage (BAL) of eight infants with SIDS, using bacteriological, light and electron microscopic methods to collect data about the role of respiratory inflammations in SIDS children and to determine the usefulness of the BAL technique. Findings are discussed.

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References

  1. Beckwith JB (1973) The sudden infant death syndrome. Curr Probl Pediatr 3: 1–6

    PubMed  CAS  Google Scholar 

  2. Berry PJ (1992) Pathological findings in SIDS. J Clin Pathol 45 [Suppl] 11–16

    PubMed  CAS  Google Scholar 

  3. Blackwell CC, Saadi AT, Raza MW, Stewart J, Weir DM (1992) Susceptibility to infection in relation to SIDS. J Clin Pathol 45 [Suppl] 20–24

    PubMed  CAS  Google Scholar 

  4. Csabai T (1987) The oppinion of a forensic physician about SIDS (in Hungarian). Hung Med 17: 128

    Google Scholar 

  5. Fleming KA (1992) Viral respiratory infection and SIDS. J Clin Pathol 45 [Suppl 11]: 29–32

    PubMed  CAS  Google Scholar 

  6. Fleming PJ, Azaz Y, Wigfield R (1992) Development of thermoregulation in infancy, possible implications for SIDS. J Clin Pathol 45 [Suppl 11]: 17–29

    PubMed  CAS  Google Scholar 

  7. Forsyth KD, Bradlsy J, Weeks SC, Smith M (1988) Immunocytologic characterization using monoclonal antibodies of lung lavage cell phenotype in infants who have died of SIDS. Pediatr Res 23: 187–190

    PubMed  CAS  Google Scholar 

  8. Gilbert R (1994) The changing epidemiology of SIDS. Arch Dis Child 70: 445–449

    PubMed  CAS  Google Scholar 

  9. Gilbert R, Rudd P, Berry PJ, Fleming PJ (1992) Combined effect of infection and heavy wrapping on the risk of sudden unexpected infant death. Arch Dis Child 67: 171–177

    PubMed  CAS  Google Scholar 

  10. Gould S, Keeling JW, Fleming KA (1993) Role of respiratory viral infection in SIDS: detection of viral nucleic acid by in situ hybridization. J Pathol 171: 271–278

    Article  PubMed  Google Scholar 

  11. Howatson AG (1992) Viral infection and alpha interferon in SIDS. J Clin Pathol 45 [Suppl 11]: 25–28

    PubMed  CAS  Google Scholar 

  12. Hunninghake GW, Gadek JE, Kawanami O, Ferrans VJ, Crystal RG (1979) Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am J Pathol 97: 1

    Google Scholar 

  13. James D, Berry PJ, Fleming P, Hathaway M (1990) Surfactant abnormality and SIDS, a primary or secondary phenomenon? Arch Dis Child 65: 774–778

    Article  PubMed  CAS  Google Scholar 

  14. Központi Statisztikai Hivatal Budapest Demográfiai Évkönyv (1992) English Suppl. of Demographic Yearbook, Budapest 1992 VIII: 284–306

    Google Scholar 

  15. Lundemose JB, Smith H, Sweet C (1993) Cytokine release from human peripheral blood leucocytes incubated with endotoxin and without prior infection with influenza virus: relevance to sudden infant death syndrome. Int J Exp Pathol 74: 291–297

    PubMed  CAS  Google Scholar 

  16. Milner AD (1987) Recent theories on the cause of cot deaths. BMJ 295: 1366–1368

    PubMed  CAS  Google Scholar 

  17. Morris JA, Haran D, Smith A (1987) Hypothesis: common bacterial toxins are possible cause of SIDS. Med Hypotheses 22: 11–22

    Article  Google Scholar 

  18. Reynolds HY (1987) Bronchoalveolar lavage. Am Rev Respir Dis 135: 250–263

    PubMed  CAS  Google Scholar 

  19. Rimmel F, Goding GS (1993) Cholinergic agents in the laryngeal chemoreflex model of SIDS. Laryngoscope 103: 623–629

    Google Scholar 

  20. Romhányi G, Deák G, Fischer I (1975) Aldehyde-bisulfitetoluidineblue (ABT) staining as topooptical reaction for demonstration of linear order of vicinal-OH groups in biological structures. Histochemistry 43: 333–348

    Article  PubMed  Google Scholar 

  21. Saadi AT, Blackwell CC, Raza MW, James VS (1993) Factors enhancing adherence of toxigenicStaphylococcus aureus to epithelial cells and their possible role in SIDS. Epidemiol Infect 110:507–517

    Article  PubMed  CAS  Google Scholar 

  22. Schuller D, Klinger A (1987) Sudden death in infancy. Hung Med J 128: 2295–2300

    Google Scholar 

  23. Sutton PN, Emery JL (1966) Sudden death in infancy, a microbial and epidemiological study. Arch Dis Child 67: 171–177

    Google Scholar 

  24. Telford DR, Morris JA, Hughes P (1989) The nasopharyngeal bacterial flora in SIDS. J Infect 18: 125–130

    Article  PubMed  CAS  Google Scholar 

  25. Valdes-Dapena MA (1967) Sudden and unexpected death in infancy. A review of the world literature 1954–1966. Pediatrics 39: 123–138

    PubMed  CAS  Google Scholar 

  26. Williams AL, Uren CE, Bretherton L (1984) Respiratory viruses and SIDS. BMJ 288: 1491–1493

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Oto-Rhino-Laryngology, Bethesda Children's Hospital, Hungarian Presbyterian Church, Budapest, Hungary

    L. Imrei

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  1. L. Imrei
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Imrei, L. Studies of bronchoalveolar lavage in sudden infant death syndrome: A clinical-pathological study. Eur Arch Otorhinolaryngol 254 (Suppl 1), S43–S45 (1997). https://doi.org/10.1007/BF02439720

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