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Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats


Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 μg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 μg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.

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Wytske Fokkens, Peter Hellings & Christine Segboer


  1. Baudoin T, Ferencic Z, Ries S, Kalogjera L (1993) Evolution of neurogenic inflammation for capsaicin-induced rhinitis in the rats. Symp Otorhinol (Zagreb) 28: 35–40

    Google Scholar 

  2. Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide, and other neuropeptides. Neuroscience 24: 739–768

    Article  PubMed  CAS  Google Scholar 

  3. Kalogjera L, Baudoin T, Ferencic Z, Sikiric P (1996) Protection of cromolyn and BPC 157 on capsaicin induced rhinitis in rats. Allergologie 19: 51

    Google Scholar 

  4. Matsuda H, Kawakita K, Kiso Y, Nakano T, Kitamura Y (1989) Substance P induces granulocyte infiltration through degranulation of mast cells. J Immunol 142: 927–931

    PubMed  CAS  Google Scholar 

  5. Petersson G, Malm L, Ekman R, Hakanson R (1989) Capsaicin evokes secretion of nasal fluid and depletes substance P and CGRP from the nasal mucosa in rat. Br J Pharmacol 98: 930–936

    PubMed  CAS  Google Scholar 

  6. Pipkorn U (1983) Effect of topical glucocorticoid treatment on nasal mucosal mast cells in allergic rhinitis. Allergy 38: 125–129

    PubMed  CAS  Google Scholar 

  7. Sikiric P, Petek M, Rueman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N (1993) A new gastric juice peptide, BPC — an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87: 313–327

    Article  CAS  Google Scholar 

  8. Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkivc I, Mise S, Zoricic I, Gjurasin M, Konjevoda P, Separovic J, Ljubanovic D, Artukovic B, Bratulic M, Tisljar M, Jurina L, Buljat G, Miklic P, Marovic A (1996) The beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin and capsaicin neurotoxicity. Dig Dis Sci 41: (in press)

  9. Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A (1992) BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272: 417–22

    Google Scholar 

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Kalogjera, L., Ries, M., Baudoin, T. et al. Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats. Eur Arch Otorhinolaryngol 254 (Suppl 1), S9–S11 (1997).

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