Abstract
Rabbit aortic rings relaxed with an increase in cyclic guanosine monophosphate and cyclic adenosine monophosphate content in response to exposure to organ fluid of isolated cochleas of the guinea pig following field stimulation (50 Hz, 80 V, 0.2 ms). Relaxations were blocked by 30 μMN G-nitro-l-arginine methyl ester added to the vessel rings. This inhibitory effect was reversed by 3 MMl-arginine. Removal of the vascular endothelium also blocked the relaxation response. Glibenclamide attenuated vasorelaxation in a concentration-dependent manner. We conclude that cochlear nerve stimulation induces an endothelium-dependent vasorelaxation involving activation of adenosine triphosphate-sensitive potassium channels.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chu C, Nenov, A, Skellett R, Fallon M, Bright L, Norris CH, Bobbin RP (1995) Nitroprusside suppresses cochlear potentials and outer hair cell responses. Hear Res 87: 1–8
Erostegui C, Norris CH, Bobbin RP (1994) In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells. Hear Res 74: 135–147
Furchgott RF, Zawadzki JV (1980) The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373–376
Lazdunski M (1994) ATP-sensitive potassium channels: an overview. J Cardiovasc Pharmacol 24 [Suppl 4]: S1-S5
Moncada S, Palmer RJM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109–142
Nelson MT, Huang Y, Brayden JE, Hescheler J, Standen NB (1990) Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature 344: 770–773
Plinkert PK, Zenner HP, Heilbronn E (1991) A nicotinic acetylcholine receptor-like alpha-bungarotoxin binding site on outer hair cells. Hear Res 53: 123–130
Szilvassy Z, Jakab I, Bor P, Koltai M, Tarrade T, Esanu A, Braquet P, Lonovics J (1993) Cicletanine attenuates overdrive pacing-induced global myocardial ischaemia in rabbits: possible role of cardiac cyclic nucleotides. Coronary Artery Dis 4: 443–452
Taylor SG, Weston AH (1988) Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium. Trends Pharmacol Sci 9: 272–274
Tohyama Y, Kiyama H, Kitajiri M, Yamashita T, Kumazawa T, Tohyama M (1989) Ontogeny of calcitonin gene-related peptide in the organ of Corti of the rat. Brain Res 45: 309–312
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Szilvassy, J., Ferdinandy, P., Kiss, J.G. et al. Involvement of glibenclamide-sensitive potassium channels in vasorelaxation by cochlear nerve stimulation. Eur Arch Otorhinolaryngol 254 (Suppl 1), S6–S8 (1997). https://doi.org/10.1007/BF02439710
Issue Date:
DOI: https://doi.org/10.1007/BF02439710