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Estrogen effects on the aortic wall in young immature rabbits

Oestrogenwirkungen auf die Aortenwand bei jungen geschlechtsunreifen Kaninchen

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Zusammenfassung

Es wurde die Oestrogenwirkung auf die Aortenwand jugendlicher geschlechtsunreifer neuseeländischer Kaninchen beiderlei Geschlechtes histologisch untersucht. Dabei wurden kleine Dosen und eine jeweils kurze Behandlungsdauer gewählt. Durch ausgedehnte Kontrollen wurde gezeigt, daß individuelle Verschiedenheiten sowohl im histologischen Bau der Aortenwand als auch bezüglich der Reagibilität der Tiere auf die gesetzten Hormonwirkungen bestanden. Die Oestrogenmedikation zeitigte eine sog. gesteigerte Aktivität der Aortenwandzellen, eine Verbreiterung der kollagenen Fibrillen und eine quantitative Vermehrung der Grundsubstanz. Unter dem Einfluß der Oestrogenmedikation wurde die Aortenwand dicker. Die mit Oestrogen behandelten Kaninchen zeigten einen signifikant niedrigeren Prozentsatz sog. spontaner Arteriosklerose als die Kontrolltiere.

Summary

The effect of estrogen (estradiol) on the aortic wall of immature young (New Zealand) rabbits of both sexes was studied with the light microscope. The hormone was given in small doses for short periods. Comparative studies of the aortas of control animals showed the known individual variations in the histology of the vessel wall. The studies of the estrogen-treated animals revealed the well-known variable response to hormonal effects. Estrogen in experimental animals induced progressive changes: cellular hyperactivity with proliferation, an increase in the amount of ground substance, and an enlargement of collagenous fibers. These changes were essentially those known as extra-genital estrogen effects observed in many other animal species. Estrogen changed the aortic wall making it stronger. The estrogen animals had a significantly lower percentage of spontaneous arteriosclerosis than did the control animals.

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Authors and Affiliations

  1. Department of Pathology (Clinical and Research Laboratories) of the VA Hospital, 62959, Marion, Illinois, USA

    D. Gostimirovich

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  1. D. Gostimirovich
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Aided by Grant of Veterans Administration Medical Research Appropriation 360161.101 (016).

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Gostimirovich, D. Estrogen effects on the aortic wall in young immature rabbits. Virchows Arch. path Anat. 343, 258–264 (1968). https://doi.org/10.1007/BF02439574

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  • DOI: https://doi.org/10.1007/BF02439574

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