Abstract
Effects of dexamethasone on the ability of nonadherent bone marrow cells to inhibit proliferation of mastocytoma P815 cells and concanavalin A-stimulated proliferation of syngeneic splenocytes were studied. Antitumor activity of cells increased, but their natural suppressor activity decreased in the presence of dexamethasone. Pretreatment with dexamethasone (for 3 h) did not affect the sensitivity of mastocytoma cells to antitumor factors and the antitumor activity of bone marrow effectors. Pretreatment of bone marrow cells with dexamethasone for 24 h potentiated antitumor activity of their nonadherent fractions.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 459–461, April, 2000
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Bel'skaya, N.V., Stal'bovskaya, E.S., Bel'skii, Y.P. et al. Opposite effects of dexamethasone on antitumor and natural suppressor activities of bone marrow cells. Bull Exp Biol Med 129, 386–388 (2000). https://doi.org/10.1007/BF02439279
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DOI: https://doi.org/10.1007/BF02439279