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Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged antimal lifespan by 40–60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was −0.4 for IgM and −0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.

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Authors and Affiliations

  1. N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, USSR

    B. S. Amandzholov, S. M. Sitdikova, L. V. Manzyuk & F. V. Donenko

  2. Hema-Medika Research-and-Production Company, Moscow

    Yu. S. Lebedin, S. V. Chukanov & A. Yu. Toptygin

Authors
  1. B. S. Amandzholov
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  2. S. M. Sitdikova
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  3. Yu. S. Lebedin
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  4. S. V. Chukanov
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  5. A. Yu. Toptygin
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  6. L. V. Manzyuk
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  7. F. V. Donenko
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 456–458, April, 2000

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Amandzholov, B.S., Sitdikova, S.M., Lebedin, Y.S. et al. Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma. Bull Exp Biol Med 129, 383–385 (2000). https://doi.org/10.1007/BF02439278

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  • DOI: https://doi.org/10.1007/BF02439278

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