Skip to main content

Peculiarities of primary humoral immune response in mice with cytostatic disease

Bulletin of Experimental Biology and Medicine volume 129, pages 370–373 (2000)Cite this article

Abstract

Single intraperitoneal injection of cyclophosphamide in a maximum permissible dose (250 mg/kg) followed by immunization with thymus-dependent antigen (sheep erythrocytes) markedly suppressed the formation of antibody-producing cells in the spleen, especially at early stages of cytostatic disease, and delayed the synthesis of specific antibodies in male CBA/CaLac mice. Platidiam (cisplatin) injected in comparable doses 4 days before immunization practically did not suppress the formation of antibody-producing cells and their functional activity, but being injected 30 days before immunization reduced the number of antibody-producing cells.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Z. P. Bulkina,Antineoplastic Drugs [in Russian], Kiev (1991), pp. 263–271.

  2. E. D. Gol'dberg, A. M. Dygai, and V. V. Zhdanov,Role of Hemopoietic Microenvironment in Regulation of Hemopoiesis during Cytostatic Myelosuppression [in Russian], Tomsk (1999).

  3. V. A. Gorbunova, N. I. Perevodchikova, A. M. Garin,et al., Drug Therapy of Malignant Tumors and Leukosis [in Russian], Moscow (1991), pp. 94–98.

  4. V. A. Kozlov, I. N. Zhuravkin, and I. G. Tsyrlova,Stem Hemopoietic Cell and Immune Response [in Russian], Novosibirsk (1982).

  5. I. V. Kudaeva,Morphological and Functional State of Plasma Cells during Cytostatic-Induced Blood Suppression and under Conditions of Antigenic Stimulation, Abstract of Cand. Med. Sci. Dissertation, Tomsk (1997).

  6. T. I. Leont'eva, N. E. Gladkova, and B. S. Uteshev,Farmakol. Toksikol.,51, No. 6, 60–65 (1988).

    PubMed  Google Scholar 

  7. N. R. Ling and D. Ketti,Hemagglutination and Reactions of Antibody-Dependent Hemolysis [in Russian], Ed. D. Ketti, Moscow (1991), Vol. 1, pp. 238–243.

  8. E. V. Markova,Role of Prostaglandin E 2 in Regulation of IL-1 Production by Macrophages under Effects of Various Factors and during the Humoral Immune Response, Abstract of Cand. Med. Sci. Dissertation, Novosibirsk (1991).

  9. L. S. Mushtovatova, I. B. Tikhonova, Yu. V. Fedorov, and V. V. Novitskii,Pathogenesis of Pathological Processes [in Russian], Kemerovo (1994), pp. 76–78.

  10. R. V. Petrov, R. M. Khaitov, R. I. Ataullakhanov, and I. G. Sidorovich,Zh. Obshch. Biol.,39, No. 4, 572–581 (1978).

    PubMed  CAS  Google Scholar 

  11. A. F. Poveshchenko,Mechanisms of the Involvement of Prostaglandin E 2 in the Humoral Immune Response, Abstract of Cand. Med. Sci. Dissertation, Novosibirsk (1987).

  12. A. Roit,Principles of Immunology [in Russian], Moscow (1991).

  13. D. M. Samarin, G. V. Seledtsova, V. I. Seledtsov,et al., Byull. Eksp. Biol. Med.,123, No. 1, 66–70 (1997).

    CAS  Article  Google Scholar 

  14. A. J. Cunningham,Nature,207, 1106 (1965).

    PubMed  CAS  Article  Google Scholar 

  15. A. W. Thompson, C. A. McPhee, and H. F. Sewell,Immunology,63, No. 3, 477–482 (1988).

    Google Scholar 

Download references

Author information

Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, USSR

    N. V. Masnaya & G. M. Ratner

Authors
  1. N. V. Masnaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. M. Ratner
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 440–443, April, 2000

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Masnaya, N.V., Ratner, G.M. Peculiarities of primary humoral immune response in mice with cytostatic disease. Bull Exp Biol Med 129, 370–373 (2000). https://doi.org/10.1007/BF02439274

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02439274

Key Words

  • cyclophosphamide
  • Platidiam (cisplatin)
  • antibody-producing cells
  • IgM and IgG antibodies