Skip to main content
SpringerLink
Log in

Effects of antitumor drugs on offspring

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The offspring of Wistar rats obtained from parents, one of which received platinum-containing drug Platidiam (cisplatin) or anthracycline antibiotics Doxorubicin and Farmorubicin was characterized by low viability (embryonic death increased 4–30-fold compared to control) and congenital malformations. The fetuses displayed pathology in internal organs and low ossification rates. Newborn rats are characterized by low survival rate and retarded physical development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. M. Belen'kii, in:Fundmentals of Quantitative Evaluation of Pharmacological Effects [in Russian], Leningrad (1963) pp. 81–108.

  2. A. P. Dyban, V. S. Baranov, and I. M. Akimova,Arkh. Anat.,59, No. 10, 89–100 (1970).

    PubMed  CAS  Google Scholar 

  3. Anticancer Chemotherapy, Ed. N. I. Perevodchikova [in Russian], Moscow (1996).

  4. A. Genesca, R. Miro, M. R. Caballin,et al., Human Reprod.,5, No. 3, 286–290 (1990).

    CAS  Google Scholar 

  5. E. Keuser, N. Liros, and W. Hefzel,Cancer Res. Clin. Oncol., No. 3, 260–266 (1987).

    Article  Google Scholar 

  6. J.J. Kjer and T. Irersen,Br. J. Obstet. Gynaecol.,97, No. 7, 623–625 (1990).

    PubMed  CAS  Google Scholar 

  7. D. Mormor,Contracept. Fertil. Sex.,21, No. 10, 739–743 (1993).

    Google Scholar 

  8. S. Retsas, H. Mackenzie, and A. Mohith,Lancet,347, No. 9002, 687 (1996).

    Article  PubMed  CAS  Google Scholar 

  9. H. Schwabe,Dtsch. Med. Wochenschr., No. 4, 121–126 (1992).

    Article  Google Scholar 

  10. R. Sutton, A. U. Burdar, and G. N. Hortobagyl,Cancer,65, No. 4, 847–850 (1990).

    Article  PubMed  CAS  Google Scholar 

  11. K. L. Witt and J. Bishop,Mutat. Res.,355, No. 1-2, 209–234 (1996).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, USSR

    E. D. Gol'dberg, T. G. Borovskaya & M. E. Poluektova

Authors
  1. E. D. Gol'dberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. G. Borovskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. E. Poluektova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 437–439, April, 2000

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gol'dberg, E.D., Borovskaya, T.G. & Poluektova, M.E. Effects of antitumor drugs on offspring. Bull Exp Biol Med 129, 367–369 (2000). https://doi.org/10.1007/BF02439273

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02439273

Key Words

Search

Navigation