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Effect of natural antiphospholipid antibodies on antithrombotic activity of vascular wall

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Natural latent human antibodies cross-reacting with DNA and cardiolipin, interact with human endothelial cells, decrease antiaggregation activity of rat aortic wall, and increase fibrinolytic activity of the wall of the inferior vena cava. It is assumed that natural antiphospholipid antibodies present in immunoglobulin preparations in a latent state modify antithrombogenic activity of the vascular wall and are a potential cause of antiphospholipid syndrome.

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Authors and Affiliations

  1. Department of Radiation Biochemistry, Laboratory of Radiation Experimental Hematology, Medical Radiology Research Center, Russian Academy of Medical Science, Obninsk

    V. M. Zyablitskii, I. V. Lekakh, L. V. Lyubina, V. N. Romanovskaya, A. E. Kabakov, L. V. Panarina & A. M. Povernnyii

Authors
  1. V. M. Zyablitskii
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  2. I. V. Lekakh
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  3. L. V. Lyubina
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  4. V. N. Romanovskaya
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  5. A. E. Kabakov
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  6. L. V. Panarina
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  7. A. M. Povernnyii
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 417–419, April, 2000

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Zyablitskii, V.M., Lekakh, I.V., Lyubina, L.V. et al. Effect of natural antiphospholipid antibodies on antithrombotic activity of vascular wall. Bull Exp Biol Med 129, 352–354 (2000). https://doi.org/10.1007/BF02439267

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  • DOI: https://doi.org/10.1007/BF02439267

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