Abstract
Platelet and plasma monoamine oxidase activity was determined at early stages of hypothermic perfusion and circulatory arrest. Monoamine oxidase activity decreased more drastically and restored more slowly against the background of deep (14°C) compared to moderate hypothermia (25–29°C). The decrease in platelet monoamine oxidase activity was accompanied by its increase in the plasma, which attests to mechanical (in tubes) and toxic damage to platelets. The latter is associated with increased partial O2 pressure in the plasma during hypothermia, which promotes the formation of reactive oxygen species.
Similar content being viewed by others
References
A. I. Balakleevskii,Lab. Delo, No. 1, 151–153 (1976).
I. V. Verevkina and I. I. Kurilova,Vopr. Med. Khimii,24, No. 3, 137–140 (1978).
V. Z. Gorkin,Aminooxydases and Their Role in Medicine [in Russian], Moscow (1981), p. 336.
Ch. S. Guseinov,Thrombosis and Fibrinolysis in Surgery [in Russian], Moscow(1998), pp. 226–238.
A. A. Krichevskaya, I. L. Goroshinskaya, G. M. Fedorenko, and A. A. Khodakova,Neirokhimiya,5, No. 1, 37–44 (1986).
C. J. Fowler, B. A. Calingham, T. J. Mantle, and K. F. Tipton,Biochem. Pharmacol.,27, 97–101 (1978).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 393–395, April, 2000
Rights and permissions
About this article
Cite this article
Korotkina, R.N., Rudneva, V.G., Zatsepina, N.E. et al. Platelet monoamine oxidase activity during surgical intervention under condition of hypothermic perfusion. Bull Exp Biol Med 129, 332–334 (2000). https://doi.org/10.1007/BF02439259
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02439259