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Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 4, pp 332–334 | Cite as

Platelet monoamine oxidase activity during surgical intervention under condition of hypothermic perfusion

  • R. N. Korotkina
  • V. G. Rudneva
  • N. E. Zatsepina
  • L. S. Lokshin
  • L. S. Smirnov
  • A. A. Karelin
General Pathology and Pathological Physiology
  • 23 Downloads

Abstract

Platelet and plasma monoamine oxidase activity was determined at early stages of hypothermic perfusion and circulatory arrest. Monoamine oxidase activity decreased more drastically and restored more slowly against the background of deep (14°C) compared to moderate hypothermia (25–29°C). The decrease in platelet monoamine oxidase activity was accompanied by its increase in the plasma, which attests to mechanical (in tubes) and toxic damage to platelets. The latter is associated with increased partial O2 pressure in the plasma during hypothermia, which promotes the formation of reactive oxygen species.

Key Words

extracorporeal circulation hypothermia platelets monoamine oxidase 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • R. N. Korotkina
    • 1
  • V. G. Rudneva
    • 1
  • N. E. Zatsepina
    • 1
  • L. S. Lokshin
    • 1
  • L. S. Smirnov
    • 1
  • A. A. Karelin
    • 1
  1. 1.A. V. Vishnevski Institute of Surgery, Research Center of SurgeryRussian Academy of Medical SciencesUSSR

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