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Adaptation to periodic high-altitude hypoxia inhibits baroreflex vagal bradycardia in rats

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

A 3-week course of adaptation to high-altitude hypoxia (4500 m above sea level) inhibited baroreflex avagal bradycardia induced by a rapid rise of systemic blood pressure in conscious rats. Bradycardic responses to electrical stimulation of peripheral end of the right vagus nerve and methacholine (M2 muscarinic receptor agonist) in hypoxia-adapted rats did not differ from the control. It is concluded that hypoxia inhibits baroreflex vagal bradycardia by acting on a central element of the baroreceptor reflex arch

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, USSR

    M. N. Obrezchikova, O. S. Tarasova, A. S. Borovik & V. B. Koshelev

Authors
  1. M. N. Obrezchikova
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  2. O. S. Tarasova
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  3. A. S. Borovik
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  4. V. B. Koshelev
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Corresponding author

Correspondence to M. N. Obrezchikova.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 386–389, April, 2000

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Obrezchikova, M.N., Tarasova, O.S., Borovik, A.S. et al. Adaptation to periodic high-altitude hypoxia inhibits baroreflex vagal bradycardia in rats. Bull Exp Biol Med 129, 327–329 (2000). https://doi.org/10.1007/BF02439257

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  • DOI: https://doi.org/10.1007/BF02439257

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