Abstract
In vivo effects of exogenous ATP on cardiac activity were studied on adult rats. Intravenous administration of ATP produced a positive chronotropic effect, but did not affect the stroke volume. This was due to activation of type II purine receptors, rather than due to the influence of ATP hydrolysis products, since P1 receptor agonist adenosine was inefective. The blockade of β-adrenoceptors and muscarinic receptors did not modify the positive chronotropic effect of ATP, which indicated that this action was not realized via sympathetic or parasympathetic nerves. ATP applied against the background of atropine blocade produced a 4-fold increase in the variability of heart rate typical of activation of the parasympathetic myocardial regulation.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 377–380, April, 2000
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Bilalova, G.A., Anikina, T.A., Sitdikov, F.G. et al. Effect of exogenous ATP on cardiac activity in rats. Bull Exp Biol Med 129, 320–322 (2000). https://doi.org/10.1007/BF02439255
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DOI: https://doi.org/10.1007/BF02439255